Treatment of liver metastases from colorectal cancer with hepatic artery occlusion, intraportal 5-fluorouracil infusion, and oral allopurinol. A randomized clinical trial.

• Regional therapy for colorectal liver metastases aimed at prolonging survival has not been tested fully in a randomized trial with untreated control subjects. This study explored the efficacy of temporary hepatic artery occlusion followed by intraportal infusion of 5-fluorouracil (5-FU) and oral allopurinol as biochemical modulators in prolonging the survival of patients with nonresectable liver metastases and no extrahepatic cancer.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Keyword

Administration

Oral

Adult

Aged

Allopurinol

administration & dosage

Antineoplastic Combined Chemotherapy Protocols

therapeutic use

Colorectal Neoplasms

pathology

Combined Modality Therapy

Constriction

Female

Fluorouracil

administration & dosage

Hepatic Artery

surgery

Humans

Infusions

Intravenous

Liver Neoplasms

blood supply

drug therapy

secondary

therapy

Male

Middle Aged

Portal Vein

Survival Analysis

Treatment Outcome

Publication and Content Type

ref (subject category)

art (subject category)