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  • Shao, Yangzhen,1981Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory (author)

Novel rat model reveals important roles of β-adrenoreceptors in stress-induced cardiomyopathy.

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • Elsevier BV,2013

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/173544
  • https://gup.ub.gu.se/publication/173544URI
  • https://doi.org/10.1016/j.ijcard.2012.12.092DOI

Supplementary language notes

  • Language:English

Part of subdatabase

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND: Stress-induced cardiomyopathy (SIC), also known as Takotsubo cardiomyopathy, is an acute cardiac syndrome with substantial morbidity and mortality. The unique hallmark of SIC is extensive ventricular akinesia involving apical segments with preserved function in basal segments. Adrenergic overstimulation plays an important role in initiating SIC but the pathophysiological pathways and receptors involved are unknown. METHODS: Sprague Dawley rats (~300g) were injected with a single dose of the β-adrenergic agonist isoprenaline (ISO, i.p.) and echocardiography was used to study cardiac function. The akinetic part of the left ventricle was biopsied in six SIC patients. Amount of intracellular lipid and glycogen as well as degree of permanent cardiac damage were assessed by histology. RESULTS: In rats, ISO at doses ≥50mg/kg induced severe SIC-like regional akinesia that completely resolved within seven days. Intracellular lipid content was higher in akinetic, but not in normokinetic myocardium in both SIC patients and rats. β2-receptor blockade or Gi-pathway inhibition was associated with less widespread akinesia and low lipid accumulation but significantly increased acute mortality. CONCLUSIONS: We provide a novel rat model of SIC that supports the hypothesis of circulating catecholamines as initiators of SIC. We propose that the β-adrenoreceptor pathway is important in the setting of severe catecholamine overstimulation and that perturbations of cardiac metabolism occur in SIC.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Redfors, BjörnGothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xredbj (author)
  • Scharin Täng, Margareta,1962Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xscham (author)
  • Möllmann, Helge (author)
  • Troidl, Christian (author)
  • Szardien, Sebastian (author)
  • Hamm, Christian (author)
  • Nef, Holger (author)
  • Borén, Jan,1963Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xborej (author)
  • Omerovic, Elmir,1968Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xomeel (author)
  • Göteborgs universitetWallenberglaboratoriet (creator_code:org_t)

Related titles

  • In:International journal of cardiology: Elsevier BV168:3, s. 1943-19501874-17540167-5273

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