Are single nucleotide polymorphisms in the oxytocin and vasopressin 1A/1B receptor genes likely candidates for variation in ejaculatory function?

• OBJECTIVES To investigate associations between single nucleotide polymorphisms (SNPs) linked to the oxytocin, To investigate these associations in a large, population-based sample. PATIENTS AND METHODS In all, 1517 male twins and non-twin brothers of twins aged 18-45 years (mean = 26.43; SD = 4.87) A Bayesian linear mixed-effects model, which appropriately controls for between subjects dependence, We corrected for multiple testing using a linkage disequilibrium correlation measure. RESULTS We found a heterozygote effect on one SNP in the oxytocin receptor gene (rs75775), so that individuals Several SNPs in the arginine vasopressin receptor genes had rare or very rare genotypes. This study CONCLUSIONS Our results regarding the oxytocin receptor polymorphisms support previous studies that indicate a Oxytocin receptor genes are, for example, unlikely suitable targets for pharmacogenetic intervention Rare variants in arginine vasopressin receptor genes may have significant effects on premature

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)

Nyckelord

premature ejaculation

oxytocin receptor

vasopressin receptor

gene

polymorphism

population-based sample

premature ejaculation

delayed ejaculation

transporter gene

sexual desire

latency time

associations

rat

identification

localization

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)