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  • Granér, Marit (author)

Cardiac steatosis associates with visceral obesity in nondiabetic obese men.

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • The Endocrine Society,2013
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/175026
  • https://gup.ub.gu.se/publication/175026URI
  • https://doi.org/10.1210/jc.2012-3190DOI
  • https://research.chalmers.se/publication/175026URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: Liver fat and visceral adiposity are involved in the development of the metabolic syndrome (MetS). Ectopic fat accumulation within and around the heart has been related to increased risk of heart disease. The aim of this study was to explore components of cardiac steatosis and their relationship to intra-abdominal ectopic fat deposits and cardiometabolic risk factors in nondiabetic obese men. Methods: Myocardial and hepatic triglyceride (TG) contents were measured with 1.5 T magnetic resonance spectroscopy, and visceral adipose (VAT), abdominal subcutaneous tissue (SAT), epicardial and pericardial fat by magnetic resonance imaging in 37 men with the MetS and in 40 men without the MetS. Results: Myocardial and hepatic TG contents, VAT, SAT, epicardial fat volumes, and pericardial fat volumes were higher in men with the MetS compared with subjects without the MetS (P < .001). All components of cardiac steatosis correlated with SAT, VAT, and hepatic TG content and the correlations seemed to be strongest with VAT. Myocardial TG content, epicardial fat, pericardial fat, VAT, and hepatic TG content correlated with waist circumference, body mass index, high-density lipoprotein cholesterol TGs, very low-density lipoprotein-1 TGs, and the insulin-resistance homeostasis model assessment index. VAT was a predictor of TGs, high-density lipoprotein cholesterol, and measures of glucose metabolism, whereas age and SAT were determinants of blood pressure parameters. Conclusions: We suggest that visceral obesity is the best predictor of epicardial and pericardial fat in abdominally obese subjects. Myocardial TG content may present a separate entity that is influenced by factors beyond visceral adiposity.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Siren, Reijo (author)
  • Nyman, Kristofer (author)
  • Lundbom, Jesper (author)
  • Hakkarainen, Antti (author)
  • Pentikäinen, Markku O (author)
  • Lauerma, Kirsi (author)
  • Lundbom, Nina (author)
  • Adiels, Martin,1976Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institutionen för matematiska vetenskaper,Institute of Medicine, Department of Molecular and Clinical Medicine,Department of Mathematical Sciences,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg(Swepub:cth)adiels (author)
  • Nieminen, Markku S (author)
  • Taskinen, Marja-Riitta (author)
  • Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin (creator_code:org_t)

Related titles

  • In:The Journal of clinical endocrinology and metabolism: The Endocrine Society98:3, s. 1189-971945-71970021-972X

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