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Postprandial accumu...
Postprandial accumulation of chylomicrons and chylomicron remnants is determined by the clearance capacity.
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- Adiels, Martin, 1976 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Department of Mathematical Sciences,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology
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Matikainen, Niina (författare)
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Westerbacka, Jukka (författare)
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Söderlund, Sanni (författare)
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- Larsson, Thomas, 1947 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg
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- Olofsson, Sven-Olof, 1947 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg
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- Borén, Jan, 1963 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg
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Taskinen, Marja-Riitta (författare)
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(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- Engelska.
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Ingår i: Atherosclerosis. - : Elsevier BV. - 1879-1484 .- 0021-9150. ; 222:1, s. 222-8
- Relaterad länk:
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://research.cha...
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Abstract
Ämnesord
Stäng
- Objective To better understand the postprandial clearance of triglyceride-rich lipoproteins (TRLs) and its relation to the fasting kinetics of TRLs. Methods Two studies were performed on 30 male subjects: a fasting kinetic study to determine the fasting secretion and clearance rates of apolipoprotein B (apoB) 100 and triglycerides in the very low-density lipoprotein 1 and 2 (VLDL1 and VLDL2) fractions; and a postprandial study to determine the postprandial accumulation of apoB48, apoB100 and triglycerides in the chylomicron, VLDL1 and VLDL2 fractions. Results from these two studies were combined to characterize the postprandial clearance of TRLs in a physiologically relevant setting. Results Our results show that postprandial accumulation of the apoB48-carrying chylomicrons can be predicted from the clearance capacity of the lipolytic pathway, determined in the fasting state. Furthermore, we show that chylomicrons and VLDL1 particles are not cleared equally by the lipoprotein lipase pathway, and that chylomicrons seem to be the preferred substrate. Subjects with a rapid fasting lipid metabolism accumulate lower levels of postprandial triglycerides with less accumulation of apoB100 in the VLDL1 fraction and a faster transfer of apoB100 into the VLDL2 fraction. In contrast, fasting VLDL1 secretion does not predict postprandial triglyceride accumulation. Conclusions Non-fasting triglyceride levels have recently been identified as a major predictor of future cardiovascular events. Here we show that the capacity of the lipolytic pathway is a common determinant of both the fasting and non-fasting triglyceride levels and may thus play an important role in the development of dyslipemia and atherosclerosis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Adult
- Apolipoprotein B-100
- metabolism
- Apolipoprotein B-48
- metabolism
- Chylomicron Remnants
- metabolism
- Chylomicrons
- metabolism
- Fasting
- metabolism
- Humans
- Kinetics
- Lipoprotein Lipase
- metabolism
- Lipoproteins
- metabolism
- Lipoproteins
- VLDL
- metabolism
- Male
- Middle Aged
- Postprandial Period
- Triglycerides
- blood
- metabolism
- Postprandial Period
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Adiels, Martin, ...
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Matikainen, Niin ...
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Westerbacka, Juk ...
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Söderlund, Sanni
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Larsson, Thomas, ...
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Olofsson, Sven-O ...
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visa fler...
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Borén, Jan, 1963
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Taskinen, Marja- ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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Atherosclerosis
- Av lärosätet
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Göteborgs universitet
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Chalmers tekniska högskola