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Heparanase affects ...
Heparanase affects food intake and regulates energy balance in mice.
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- Karlsson-Lindahl, Linda, 1972 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,University of Gothenburg
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- Schmidt, Linnéa, 1985 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,University of Gothenburg
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- Haage, David (author)
- Umeå universitet,Fysiologi,Obstetrik och gynekologi
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- Hansson, Caroline, 1981 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,University of Gothenburg
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- Taube, Magdalena (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,University of Gothenburg
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- Egecioglu, Emil, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,University of Gothenburg
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- Tan, Ying-Xia (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Admyre, Therese (author)
- AstraZeneca, R&D Mölndal
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- Jansson, John-Olov, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,University of Gothenburg
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- Vlodavsky, Israel (author)
- Cancer and Vascular Biology Research Center, the Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
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- Li, Jin-Ping (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Lindahl, Ulf (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Dickson, Suzanne L., 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,University of Gothenburg
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(creator_code:org_t)
- 2012-03-27
- 2012
- English.
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In: PloS one. - San Francisco : Public Library of Science (PLoS). - 1932-6203. ; 7:3
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https://umu.diva-por... (primary) (Raw object)
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https://uu.diva-port... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Mutation of the melanocortin-receptor 4 (MC4R) is the most frequent cause of severe obesity in humans. Binding of agouti-related peptide (AgRP) to MC4R involves the co-receptor syndecan-3, a heparan sulfate proteoglycan. The proteoglycan can be structurally modified by the enzyme heparanase. Here we tested the hypothesis that heparanase plays a role in food intake behaviour and energy balance regulation by analysing body weight, body composition and food intake in genetically modified mice that either lack or overexpress heparanase. We also assessed food intake and body weight following acute central intracerebroventricular administration of heparanase; such treatment reduced food intake in wildtype mice, an effect that was abolished in mice lacking MC4R. By contrast, heparanase knockout mice on a high-fat diet showed increased food intake and maturity-onset obesity, with up to a 40% increase in body fat. Mice overexpressing heparanase displayed essentially the opposite phenotypes, with a reduced fat mass. These results implicate heparanase in energy balance control via the central melanocortin system. Our data indicate that heparanase acts as a negative modulator of AgRP signaling at MC4R, through cleavage of heparan sulfate chains presumably linked to syndecan-3.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Keyword
- Agouti-Related Protein
- metabolism
- Animals
- Body Composition
- Body Weight
- Crosses
- Genetic
- Dietary Fats
- Eating
- genetics
- physiology
- Energy Metabolism
- genetics
- Feeding Behavior
- Female
- Gene Expression Regulation
- Enzymologic
- Glucuronidase
- pharmacology
- Infusions
- Intraventricular
- Male
- Mice
- Mice
- Inbred C57BL
- Mice
- Knockout
- Receptor
- Melanocortin
- Type 4
- genetics
- metabolism
- Signal Transduction
- Syndecan-3
- metabolism
- alpha-MSH
- metabolism
- agouti-related protein
Publication and Content Type
- ref (subject category)
- art (subject category)
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PloS one
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To the university's database
- By the author/editor
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Karlsson-Lindahl ...
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Schmidt, Linnéa, ...
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Haage, David
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Hansson, Carolin ...
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Taube, Magdalena
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Egecioglu, Emil, ...
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show more...
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Tan, Ying-Xia
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Admyre, Therese
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Jansson, John-Ol ...
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Vlodavsky, Israe ...
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Li, Jin-Ping
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Lindahl, Ulf
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Dickson, Suzanne ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
- Articles in the publication
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PloS one
- By the university
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University of Gothenburg
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Umeå University
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Uppsala University