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Acromegaly and Cush...
Acromegaly and Cushing's syndrome due to ectopic production of GHRH and ACTH by a thymic carcinoid tumour: in vitro responses to GHRH and GHRP-6.
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- Janson, Per-Olof, 1940 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för obstetrik och gynekologi,Institute for the Health of Women and Children, Dept of Obstetrics and Gynaecology
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Svensson, J (author)
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- Bengtsson, Bengt-Åke, 1944 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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Frohman, L A (author)
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- Ahlman, Håkan, 1947 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery
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- Wängberg, Bo, 1953 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery
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- Nilsson, Ola, 1957 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery
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Nilsson, M (author)
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(creator_code:org_t)
- 1998
- 1998
- English.
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In: Clinical endocrinology. - 0300-0664. ; 48:2, s. 243-50
- Related links:
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https://gup.ub.gu.se...
Abstract
Subject headings
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- A 50-year-old male presented with diabetes mellitus and Cushing's syndrome associated with a large mediastinal mass. The levels of serum cortisol were high (1500-1800 nmol/l) without diurnal variation. Plasma ACTH levels (200-250 ng/l) and urinary excretion of cortisol were also increased. The levels of these hormones did not change in response to stimulation with corticotrophin releasing hormone (CRH) or suppression with high doses of dexamethasone. The patient had an elevated baseline GH level (7.3 mU/l), and the levels of immunoreactive GH-releasing hormone (GHRH) in eight plasma samples were markedly increased (600-1500 ng/l). Circulating levels of IGF-1, chromogranin A and neuropeptide Y (NPY) were also increased. Computer-assisted tomography and octreotide scintigraphy revealed a large mediastinal tumour and metastases in the left supraclavicular fossa. During treatment with octreotide, the baseline GH level was decreased (to 4.4 mU/l), while the GH pulse height was unchanged. Surgical removal of most of the tumour tissue resulted in a further decrease in the baseline serum GH level to a value (1.6 mU/l) about 20% of that before treatment, while the pulse height and mean GH were affected to a lesser extent. Postoperatively, circulating levels of cortisol and IGF-1 decreased, and the patient exhibited clinical improvement. Histological examination showed a neuroendocrine tumour with characteristics consistent with a foregut carcinoid of thymic origin. Immunoreactive GHRH, ACTH and NPY, but not immunoreactive GH, were detected in 80-90% of the tumour cells and the three peptides appeared to be co-localized. In primary culture, cells from this tumour displayed calcium influx in response to GHRH or GH releasing peptide-6 (GHRP-6), while there were not such responses by cells from another carcinoid not producing GHRH, ACTH or NPY. These results demonstrate a rare case of ectopic production of GHRH, ACTH and NPY, and indicate that the tumour cells were responsive to GHRH and GHRP-6 as well as octreotide.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Acromegaly
- etiology
- Adrenocorticotropic Hormone
- secretion
- Calcium
- metabolism
- Carcinoid Tumor
- complications
- metabolism
- secretion
- Chromogranin A
- Chromogranins
- blood
- Cushing Syndrome
- etiology
- Growth Hormone
- blood
- Growth Hormone-Releasing Hormone
- pharmacology
- secretion
- Hormones
- therapeutic use
- Humans
- Insulin-Like Growth Factor I
- analysis
- Male
- Middle Aged
- Neuropeptide Y
- secretion
- Octreotide
- therapeutic use
- Oligopeptides
- pharmacology
- Thymus Neoplasms
- complications
- metabolism
- secretion
- Tumor Cells
- Cultured
Publication and Content Type
- ref (subject category)
- art (subject category)
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Janson, Per-Olof ...
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Svensson, J
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Bengtsson, Bengt ...
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Frohman, L A
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Ahlman, Håkan, 1 ...
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Wängberg, Bo, 19 ...
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Nilsson, Ola, 19 ...
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Nilsson, M
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MEDICAL AND HEAL ...
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Clinical endocri ...
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University of Gothenburg