Expression of somatostatin receptors in oncocytic (Hürthle cell) neoplasia of the thyroid.

• Ten consecutive patients with Hürthle cell lesions of the thyroid (nodule/adenoma/carcinoma) were studied by (111)In-DTPA-D-Phe1-octreotide scintigraphy. Octreotide scintigraphy localized the primary Hürthle cell tumour in eight patients as distinct areas of increased uptake of radionuclide. Two patients with Hürthle cell carcinoma, previously thyroidectomized, had their metastases visualized by octreotide scintigraphy. Northern analyses showed expression of multiple somatostain receptor subtypes. Visualization of the Hürthle cell tumour may be due to a higher expression of somatostatin receptors in the lesions than in surrounding normal thyroid tissue. The tissue/blood (111)In concentration ratios for tumour samples from five patients showed clearly higher values than observed for normal connective tissue, muscle or lymph nodes. A relatively high uptake of (111)In was also observed in goiter tissue, which may lead to misinterpretations. The main indication for octreotide scintigraphy in patients with Hürthle cell carcinoma is suspicion of metastatic disease.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Adenoma

Oxyphilic

metabolism

radionuclide imaging

Adult

Aged

Aged

80 and over

Blotting

Northern

Female

Humans

Indium Radioisotopes

metabolism

Male

Middle Aged

Neoplasm Proteins

blood

metabolism

Octreotide

analogs & derivatives

diagnostic use

Pentetic Acid

analogs & derivatives

RNA

Messenger

metabolism

Receptors

Somatostatin

blood

metabolism

Thyroid Neoplasms

metabolism

radionuclide imaging

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