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Expression of somat...
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Tisell, Lars-Eric,1931Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery
(author)
Expression of somatostatin receptors in oncocytic (Hürthle cell) neoplasia of the thyroid.
- Article/chapterEnglish1999
Publisher, publication year, extent ...
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1999-02-26
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Springer Science and Business Media LLC,1999
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/176580
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https://gup.ub.gu.se/publication/176580URI
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https://doi.org/10.1038/sj.bjc.6690251DOI
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Ten consecutive patients with Hürthle cell lesions of the thyroid (nodule/adenoma/carcinoma) were studied by (111)In-DTPA-D-Phe1-octreotide scintigraphy. Octreotide scintigraphy localized the primary Hürthle cell tumour in eight patients as distinct areas of increased uptake of radionuclide. Two patients with Hürthle cell carcinoma, previously thyroidectomized, had their metastases visualized by octreotide scintigraphy. Northern analyses showed expression of multiple somatostain receptor subtypes. Visualization of the Hürthle cell tumour may be due to a higher expression of somatostatin receptors in the lesions than in surrounding normal thyroid tissue. The tissue/blood (111)In concentration ratios for tumour samples from five patients showed clearly higher values than observed for normal connective tissue, muscle or lymph nodes. A relatively high uptake of (111)In was also observed in goiter tissue, which may lead to misinterpretations. The main indication for octreotide scintigraphy in patients with Hürthle cell carcinoma is suspicion of metastatic disease.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Ahlman, Håkan,1947Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery(Swepub:gu)xahlha
(author)
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Wängberg, Bo,1953Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery(Swepub:gu)xwanbo
(author)
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Kölby, Lars,1963Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery(Swepub:gu)xkolbl
(author)
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Fjälling, M
(author)
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Forssell-Aronsson, Eva,1961Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för radiofysik,Institute of Selected Clinical Sciences, Department of Radiation Physics(Swepub:gu)xforev
(author)
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Mölne, Johan,1958Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin , Avdelningen för patologi,Institute of Laboratory Medicine, Dept of Pathology(Swepub:gu)xmolnj
(author)
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Nilsson, Ola,1957Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery(Swepub:gu)xnilol
(author)
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Göteborgs universitetInstitutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi
(creator_code:org_t)
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In:British journal of cancer: Springer Science and Business Media LLC79:9-10, s. 1579-820007-09201532-1827
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Tisell, Lars-Eri ...
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Kölby, Lars, 196 ...
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University of Gothenburg