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Allogeneic hematopo...
Allogeneic hematopoietic cell transplantation for fanconi anemia in patients with pretransplantation cytogenetic abnormalities, myelodysplastic syndrome, or acute leukemia.
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Ayas, Mouhab (author)
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Saber, Wael (author)
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Davies, Stella M (author)
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Harris, Richard E (author)
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Hale, Gregory A (author)
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Socie, Gerard (author)
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Lerademacher, Jennifer (author)
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Thakar, Monica (author)
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Deeg, H Joachim J (author)
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Al-Seraihy, Amal (author)
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Battiwalla, Minoo (author)
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Camitta, Bruce M (author)
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- Olsson, Richard (author)
- Karolinska Institutet
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Bajwa, Rajinder S (author)
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Bonfim, Carmem M (author)
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Pasquini, Ricardo (author)
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Macmillan, Margaret L (author)
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George, Biju (author)
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Copelan, Edward A (author)
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Wirk, Baldeep (author)
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Al Jefri, Abdullah (author)
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- Fasth, Anders, 1945 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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Guinan, Eva C (author)
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Horn, Biljana N (author)
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Lewis, Victor A (author)
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Slavin, Shimon (author)
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Stepensky, Polina (author)
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Bierings, Marc (author)
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Gale, Robert Peter (author)
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(creator_code:org_t)
- 2013
- 2013
- English.
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In: Journal of Clinical Oncology. - 0732-183X .- 1527-7755. ; 31:13, s. 1669-76
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- PURPOSE Allogeneic hematopoietic cell transplantation (HCT) can cure bone marrow failure in patients with Fanconi anemia (FA). Data on outcomes in patients with pretransplantation cytogenetic abnormalities, myelodysplastic syndrome (MDS), or acute leukemia have not been separately analyzed. PATIENTS AND METHODS We analyzed data on 113 patients with FA with cytogenetic abnormalities (n = 54), MDS (n = 45), or acute leukemia (n = 14) who were reported to the Center for International Blood and Marrow Transplant Research from 1985 to 2007. Results Neutrophil recovery occurred in 78% and 85% of patients at days 28 and 100, respectively. Day 100 cumulative incidences of acute graft-versus-host disease grades B to D and C to D were 26% (95% CI, 19% to 35%) and 12% (95% CI, 7% to 19%), respectively. Survival probabilities at 1, 3, and 5 years were 64% (95% CI, 55% to 73%), 58% (95% CI, 48% to 67%), and 55% (95% CI, 45% to 64%), respectively. In univariate analysis, younger age was associated with superior 5-year survival (≤ v > 14 years: 69% [95% CI, 57% to 80%] v 39% [95% CI, 26% to 53%], respectively; P = .001). In transplantations from HLA-matched related donors (n = 82), younger patients (≤ v > 14 years: 78% [95% CI, 64% to 90%] v 34% [95% CI, 20% to 50%], respectively; P < .001) and patients with cytogenetic abnormalities only versus MDS/acute leukemia (67% [95% CI, 52% to 81%] v 43% [95% CI, 27% to 59%], respectively; P = .03) had superior 5-year survival. CONCLUSION Our analysis indicates that long-term survival for patients with FA with cytogenetic abnormalities, MDS, or acute leukemia is achievable. Younger patients and recipients of HLA-matched related donor transplantations who have cytogenetic abnormalities only have the best survival.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- By the author/editor
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Ayas, Mouhab
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Saber, Wael
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Davies, Stella M
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Harris, Richard ...
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Hale, Gregory A
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Socie, Gerard
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show more...
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Lerademacher, Je ...
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Thakar, Monica
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Deeg, H Joachim ...
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Al-Seraihy, Amal
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Battiwalla, Mino ...
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Camitta, Bruce M
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Olsson, Richard
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Bajwa, Rajinder ...
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Bonfim, Carmem M
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Pasquini, Ricard ...
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Macmillan, Marga ...
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George, Biju
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Copelan, Edward ...
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Wirk, Baldeep
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Al Jefri, Abdull ...
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Fasth, Anders, 1 ...
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Guinan, Eva C
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Horn, Biljana N
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Lewis, Victor A
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Slavin, Shimon
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Stepensky, Polin ...
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Bierings, Marc
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Gale, Robert Pet ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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Journal of Clini ...
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University of Gothenburg
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Karolinska Institutet