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Outcomes of allogen...
Outcomes of allogeneic hematopoietic cell transplant in patients with dyskeratosis congenita.
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Gadalla, Shahinaz M (author)
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Sales-Bonfim, Carmem (author)
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Carreras, Jeanette (author)
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Alter, Blanche P (author)
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Antin, Joseph H (author)
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Ayas, Mouhab (author)
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Bodhi, Prasad (author)
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Davis, Jeffrey (author)
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Davies, Stella M (author)
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Deconinck, Eric (author)
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Deeg, H Joachim (author)
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Duerst, Reggie E (author)
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- Fasth, Anders, 1945 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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Ghavamzadeh, Ardeshir (author)
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Giri, Neelam (author)
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Goldman, Frederick D (author)
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Kolb, E Anders (author)
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Krance, Robert (author)
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Kurtzberg, Joanne (author)
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Leung, Wing H (author)
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Srivastava, Alok (author)
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Or, Reuven (author)
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Richman, Carol M (author)
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Rosenberg, Philip S (author)
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Sanchez de Toledo Codina, Jose (author)
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Shenoy, Shalini (author)
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Socié, Gerard (author)
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Tolar, Jakub (author)
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Williams, Kirsten M (author)
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Eapen, Mary (author)
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Savage, Sharon A (author)
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(creator_code:org_t)
- Elsevier BV, 2013
- 2013
- English.
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In: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. - : Elsevier BV. - 1523-6536. ; 19:8, s. 1238-1243
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http://www.bbmt.org/...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- We describe outcomes after allogeneic transplantation in 34 patients with dyskeratosis congenita transplanted between 1981 and 2009. The median age at transplantation was 13 years (range 2 - 35). Approximately 50% of transplants were from related donors. Bone marrow was the predominant source of stem cells (n=24/34). The day-28 probability of neutrophil recovery was 73% and the day-100 platelet recovery was 72%. The day-100 probability of grade II-IV acute GVHD and the 3-year probability of chronic GVHD were 24% and 37%, respectively. The 10-year probability of survival was 30%; 14 patients were alive at last follow-up. Ten deaths occurred within 4 months from transplantation due to graft failure (n=6) or other transplant-related complications; 9 of these patients had been transplanted from mismatched related or from unrelated donors. Another 10 deaths occurred after 4 months; 6 of them occurred more than 5 years from transplantation, 4 of these were attributed to pulmonary failure. Transplant-regimen intensity and transplants from mismatched related or unrelated donors were associated with early mortality. Transplantation of grafts from HLA-matched siblings with cyclophosphamide-containing non-radiation regimens was associated with early low toxicity. Late mortality was attributed mainly to pulmonary complications and likely related to the underlying disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- Hematopoietic stem cell transplantation
- dyskeratosis congenita
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Gadalla, Shahina ...
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Sales-Bonfim, Ca ...
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Carreras, Jeanet ...
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Alter, Blanche P
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Antin, Joseph H
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Ayas, Mouhab
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show more...
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Bodhi, Prasad
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Davis, Jeffrey
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Davies, Stella M
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Deconinck, Eric
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Deeg, H Joachim
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Duerst, Reggie E
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Fasth, Anders, 1 ...
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Ghavamzadeh, Ard ...
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Giri, Neelam
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Goldman, Frederi ...
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Kolb, E Anders
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Krance, Robert
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Kurtzberg, Joann ...
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Leung, Wing H
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Srivastava, Alok
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Or, Reuven
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Richman, Carol M
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Rosenberg, Phili ...
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Sanchez de Toled ...
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Shenoy, Shalini
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Socié, Gerard
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Tolar, Jakub
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Williams, Kirste ...
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Eapen, Mary
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Savage, Sharon A
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
- Articles in the publication
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Biology of blood ...
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Biology of Blood ...
- By the university
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University of Gothenburg