Search: (WFRF:(Winblad Bengt)) pers:(Blennow Kaj 1958) >
Encapsulated cell b...
Encapsulated cell biodelivery of nerve growth factor to the Basal forebrain in patients with Alzheimer's disease.
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- Eriksdotter-Jönhagen, Maria (author)
- Karolinska Institutet
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- Linderoth, Bengt (author)
- Karolinska Institutet
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- Lind, Göran (author)
- Karolinska Institutet
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Aladellie, Layth (author)
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- Almkvist, Ove (author)
- Stockholms universitet,Karolinska Institutet,Psykologiska institutionen
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- Andreasen, Niels (author)
- Karolinska Institutet
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Bogdanovic, Nenad (author)
- Karolinska Institutet
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- Jelic, Vesna (author)
- Karolinska Institutet
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Kadir, Ahmadul (author)
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- Nordberg, Agneta (author)
- Karolinska Institutet
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- Sundström, Erik (author)
- Karolinska Institutet
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- Wahlund, Lars-Olof (author)
- Karolinska Institutet
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- Wall, Anders (author)
- Uppsala universitet,Enheten för nuklearmedicin och PET
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- Wiberg, Maria (author)
- Karolinska Institutet
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- Winblad, Bengt (author)
- Karolinska Institutet
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- Seiger, Ake (author)
- Karolinska Institutet
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- Almqvist, Per (author)
- Karolinska Institutet
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Wahlberg, Lars (author)
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(creator_code:org_t)
- 2012-02-22
- 2012
- English.
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In: Dementia and geriatric cognitive disorders. - : S. Karger AG. - 1421-9824 .- 1420-8008. ; 33:1, s. 18-28
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Degeneration of cholinergic neurons in the basal forebrain correlates with cognitive decline in patients with Alzheimer's disease (AD). Targeted delivery of exogenous nerve growth factor (NGF) has emerged as a potential AD therapy due to its regenerative effects on the basal forebrain cholinergic neurons in AD animal models. Here we report the results of a first-in-man study of encapsulated cell (EC) biodelivery of NGF to the basal forebrain of AD patients with the primary objective to explore safety and tolerability.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Keyword
- Aged
- Aged
- 80 and over
- Alzheimer Disease
- drug therapy
- Autopsy
- Biopsy
- Cell Line
- Cerebral Cortex
- pathology
- Cognition
- physiology
- Dose-Response Relationship
- Drug
- Electroencephalography
- Feasibility Studies
- Female
- Humans
- Infusion Pumps
- Implantable
- adverse effects
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Nerve Growth Factors
- administration & dosage
- pharmacokinetics
- therapeutic use
- Neuropsychological Tests
- Neurosurgical Procedures
- Nicotine
- pharmacokinetics
- Positron-Emission Tomography
- Prosencephalon
- physiology
- Receptors
- Nicotinic
- metabolism
- Treatment Outcome
- nerve growth factor
- Psychology
- Psychology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Eriksdotter-Jönh ...
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Linderoth, Bengt
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Lind, Göran
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Aladellie, Layth
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Almkvist, Ove
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Andreasen, Niels
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show more...
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Blennow, Kaj, 19 ...
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Bogdanovic, Nena ...
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Jelic, Vesna
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Kadir, Ahmadul
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Nordberg, Agneta
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Sundström, Erik
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Wahlund, Lars-Ol ...
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Wall, Anders
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Wiberg, Maria
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Winblad, Bengt
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Seiger, Ake
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Almqvist, Per
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Wahlberg, Lars
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- SOCIAL SCIENCES
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SOCIAL SCIENCES
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and Psychology
- Articles in the publication
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Dementia and ger ...
- By the university
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University of Gothenburg
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Karolinska Institutet
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Stockholm University
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Uppsala University