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Characterization of...
Characterization of Human Thymic Exosomes
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- Skogberg, Gabriel (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,University of Gothenburg, Sweden
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- Gudmundsdottir, Judith (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Clinical Sciences, Department of Pediatrics,Institute of Medicine, Department of Rheumatology and Inflammation Research,University of Gothenburg, Sweden
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- van der Post, Sjoerd, 1981 (author)
- Gothenburg University,Göteborgs universitet,Core Facilities, Proteomics,Core Facilities, Proteomics,University of Gothenburg, Sweden
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- Sandström, Kerstin (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,University of Gothenburg, Sweden
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- Bruhn, Sören (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet
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- Benson, Mikael (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet
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- Mincheva-Nilsson, Lucia (author)
- Umeå universitet,Klinisk immunologi,Umeå University, Sweden
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- Baranov, Vladimir (author)
- Umeå universitet,Klinisk immunologi,Umeå University, Sweden
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- Telemo, Esbjörn, 1953 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,University of Gothenburg, Sweden
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- Ekwall, Olov, 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Clinical Sciences, Department of Pediatrics,Institute of Medicine, Department of Rheumatology and Inflammation Research,University of Gothenburg, Sweden
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(creator_code:org_t)
- 2013-07-02
- 2013
- English.
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In: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 8:7
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Abstract
Subject headings
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- Exosomes are nanosized membrane-bound vesicles that are released by various cell types and are capable of carrying proteins, lipids and RNAs which can be delivered to recipient cells. Exosomes play a role in intercellular communication and have been described to mediate immunologic information. In this article we report the first isolation and characterization of exosomes from human thymic tissue. Using electron microscopy, particle size determination, density gradient measurement, flow cytometry, proteomic analysis and microRNA profiling we describe the morphology, size, density, protein composition and microRNA content of human thymic exosomes. The thymic exosomes share characteristics with previously described exosomes such as antigen presentation molecules, but they also exhibit thymus specific features regarding surface markers, protein content and microRNA profile. Interestingly, thymic exosomes carry proteins that have a tissue restricted expression in the periphery which may suggest a role in T cell selection and the induction of central tolerance. We speculate that thymic exosomes may provide the means for intercellular information exchange necessary for negative selection and regulatory T cell formation of the developing thymocytes within the human thymic medulla.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- promiscuous gene-expression
- mhc class-ii
- epithelial-cells
- dendritic
- cells
- antigen presentation
- t-cells
- self-antigen
- tolerance
- proteins
- vesicles
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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Skogberg, Gabrie ...
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Gudmundsdottir, ...
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van der Post, Sj ...
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Sandström, Kerst ...
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Bruhn, Sören
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Benson, Mikael
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Mincheva-Nilsson ...
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Baranov, Vladimi ...
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Telemo, Esbjörn, ...
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Ekwall, Olov, 19 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Plos One
- By the university
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University of Gothenburg
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Umeå University
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Linköping University