Recent Trends in Heterocyclic Quinones

• Hetrocyclic quinones are plant secondary metabolites that have found numerous applications. Resulting from exhaustive studies of the past decades, their biological activity in relation to a variety of diseases was reported and countless attempts for development of synthetic routes to their analogues with improved pharmacological properties were published. Unnoticed for many, they have been around as drugs and drug precursors since long. This review provides an overview on the latest trends of the chemistry of hetrocyclic quinones with focus on the most impactful results of the past two decades; however, in certain cases it goes back to the ‘80s to provide the necessary context. The structural groups mitomycins, streptonigrin, isoquinolones, kinamycins, mimosamycins, azaanthraquinones, secobatzellines, pyrano- and furanonaphthoquinones, dimeric heterocyclic quinones, kalafungins and nanaomycines are discussed with respect to their biosynthesis, synthesis and biological activities.

Ämnesord

NATURVETENSKAP  -- Kemi -- Organisk kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Organic Chemistry (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medicinal Chemistry (hsv//eng)

Nyckelord

natural product

quinone

Publikations- och innehållstyp

ref (ämneskategori)

kap (ämneskategori)