id:"swepub:oai:gup.ub.gu.se/185476"
Search: id:"swepub:oai:gup.ub.gu.se/185476" > Immunotherapeutic s...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Martner, Anna,1979Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center (author)
Immunotherapeutic strategies for relapse control in acute myeloid leukemia
- Article/chapterEnglish2013
Publisher, publication year, extent ...
- Elsevier BV,2013
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/185476
- https://gup.ub.gu.se/publication/185476URI
- https://doi.org/10.1016/j.blre.2013.06.006DOI
Supplementary language notes
- Language:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Despite that the initial phases of chemotherapy induce disappearance of leukemic cells in many patients with acute myeloid leukemia (AML), the prevention of life-threatening relapses in the post-remission phase remains a significant clinical challenge. Allogeneic bone marrow transplantation, which is available for a minority of patients, efficiently prevents recurrences of leukemia by inducing immune-mediated elimination of leukemic cells, and over the past decades, numerous immunotherapeutic protocols have been developed aiming to mimic the graft-versus-leukemia reaction for the prevention of relapse. Here we review past and present strategies for relapse control with focus on overcoming leukemia-related immunosuppression in AML. We envisage future treatment protocols, in which systemic immune activators, such as vaccines, dendritic cell-based therapies, engineered variants of IL-2, or IL-15, are combined with agents that counter immunosuppression mediated by, e.g., the PD/PDL interaction, CTLA-4, CD200, reactive oxygen species, IDO expression, CXCR4, or the KIR/class I interaction, based on characteristics of the prevailing malignant clone. This combinatorial approach may pave the way for individualized immunotherapy in AML.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- Acute myeloid leukemia
- Maintenance therapy
- Leukemia-related immunosuppression
- REGULATORY T-CELLS
- ACUTE MYELOGENOUS LEUKEMIA
- BONE-MARROW-TRANSPLANTATION
- POST-CONSOLIDATION IMMUNOTHERAPY
- REMISSION
- MAINTENANCE THERAPY
- ACUTE PROMYELOCYTIC LEUKEMIA
- KIR LIGAND
- INCOMPATIBILITY
- HUMORAL IMMUNE-RESPONSES
- 1ST COMPLETE REMISSION
- LOW-DOSE INTERLEUKIN-2
Added entries (persons, corporate bodies, meetings, titles ...)
- Bergh Thorén, Fredrik,1976Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center(Swepub:gu)xthofr (author)
- Aurelius, Johan,1980Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center(Swepub:gu)xaurjo (author)
- Hellstrand, Kristoffer,1956Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center(Swepub:gu)xhellk (author)
- Göteborgs universitetSahlgrenska Cancer Center (creator_code:org_t)
Related titles
- In:Blood Reviews: Elsevier BV27:5, s. 209-2160268-960X
Internet link
Find in a library
- Blood Reviews (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Martner, Anna, 1 ...
- Bergh Thorén, Fr ...
- Aurelius, Johan, ...
- Hellstrand, Kris ...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Cancer and Oncol ...
- Articles in the publication
- Blood Reviews
- By the university
- University of Gothenburg
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
