WFRF:(Horsburgh M. J.)
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- Kenny, J. G. (author)
Mannitol Utilisation is Required for Protection of Staphylococcus aureus from Human Skin Antimicrobial Fatty Acids
- Article/chapterEnglish2013
Publisher, publication year, extent ...
- 2013-07-04
- Public Library of Science (PLoS),2013
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/185487
- https://gup.ub.gu.se/publication/185487URI
- https://doi.org/10.1371/journal.pone.0067698DOI
Supplementary language notes
- Language:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Mannitol (Mtl) fermentation, with the subsequent production of acid, is a species signature of Staphylococcus aureus, and discriminates it from most other members of the genus. Inactivation of the gene mtlD, encoding Mtl-1-P dehydrogenase was found to markedly reduce survival in the presence of the antimicrobial fatty acid, linoleic acid. We demonstrate that the sugar alcohol has a potentiating action for this membrane-acting antimicrobial. Analysis of cellular metabolites revealed that, during exponential growth, the mtlD mutant accumulated high levels of Mtl and Mtl-P. The latter metabolite was not detected in its isogenic parent strain or a deletion mutant of the entire mtlABFD operon. In addition, the mtlD mutant strain exhibited a decreased MIC for H2O2, however virulence was unaffected in a model of septic arthritis.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
- BACILLUS-SUBTILIS
- ANTIBACTERIAL ACTIVITY
- STRESS RESISTANCE
- OXIDATIVE
- STRESS
- IN-VIVO
- VIRULENCE
- EXPRESSION
- LIPIDS
- STARVATION
- ABSCESSES
Added entries (persons, corporate bodies, meetings, titles ...)
- Moran, J. (author)
- Kolar, S. L. (author)
- Ulanov, A. (author)
- Li, Z. (author)
- Shaw, L. N. (author)
- Josefsson, Elisabet,1966Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xjosel (author)
- Horsburgh, M. J. (author)
- Göteborgs universitetInstitutionen för medicin, avdelningen för reumatologi och inflammationsforskning (creator_code:org_t)
Related titles
- In:Plos One: Public Library of Science (PLoS)8:71932-6203
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