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Human Health Risk A...
Human Health Risk Assessment (HHRA) for Environmental Development and Transfer of Antibiotic Resistance
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Ashbolt, N. J. (författare)
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Amezquita, A. (författare)
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- Backhaus, Thomas, 1967 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biologi och miljövetenskap,Department of Biological and Environmental Sciences
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Borriello, P. (författare)
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Brandt, K. K. (författare)
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Collignon, P. (författare)
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Coors, A. (författare)
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Finley, R. (författare)
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Gaze, W. H. (författare)
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Heberer, T. (författare)
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Lawrence, J. R. (författare)
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- Larsson, D. G. Joakim, 1969 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
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McEwen, S. A. (författare)
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Ryan, J. J. (författare)
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Schonfeld, J. (författare)
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Silley, P. (författare)
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Snape, J. R. (författare)
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Van den Eede, C. (författare)
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Topp, E. (författare)
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(creator_code:org_t)
- Environmental Health Perspectives, 2013
- 2013
- Engelska.
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Ingår i: Environmental Health Perspectives. - : Environmental Health Perspectives. - 0091-6765 .- 1552-9924. ; 121:9, s. 993-1001
- Relaterad länk:
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Only recently has the environment been clearly implicated in the risk of antibiotic resistance to clinical outcome, but to date there have been few documented approaches to formally assess these risks. OBJECTIVE: We examined possible approaches and sought to identify research needs to enable human health risk assessments (HHRA) that focus on the role of the environment in the failure of anti-biotic treatment caused by antibiotic-resistant pathogens. METHODS: The authors participated in a workshop held 4-8 March 2012 in Quebec, Canada, to define the scope and objectives of an environmental assessment of antibiotic-resistance risks to human health. We focused on key elements of environmental-resistance-development "hot spots," exposure assessment (unrelated to food), and dose response to characterize risks that may improve antibiotic-resistance management options. DISCUSSION: Various novel aspects to traditional risk assessments were identified to enable an assessment of environmental antibiotic resistance. These include a) accounting for an added selective pressure on the environmental resistome that, over time, allows for development of antibiotic-resistant bacteria (ARB); b) identifying and describing rates of horizontal gene transfer (HGT) in the relevant environmental " hot spot" compartments; and c) modifying traditional dose-response approaches to address doses of ARB for various health outcomes and pathways. CONCLUSIONS: We propose that environmental aspects of antibiotic-resistance development be included in the processes of any HHRA addressing ARB. Because of limited available data, a multi-criteria decision analysis approach would be a useful way to undertake an HHRA of environmental antibiotic resistance that informs risk managers.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Nyckelord
- WATER TREATMENT-PLANT
- MULTICRITERIA DECISION-ANALYSIS
- BACTERIAL
- COMMUNITY TOLERANCE
- HOSPITAL WASTE-WATER
- DRINKING-WATER
- ANTIMICROBIAL
- RESISTANCE
- ESCHERICHIA-COLI
- MICROBIAL PATHOGENS
- AQUATIC ENVIRONMENT
- HORIZONTAL TRANSFER
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Till lärosätets databas
- Av författaren/redakt...
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Ashbolt, N. J.
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Amezquita, A.
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Backhaus, Thomas ...
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Borriello, P.
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Brandt, K. K.
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Collignon, P.
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visa fler...
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Coors, A.
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Finley, R.
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Gaze, W. H.
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Heberer, T.
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Lawrence, J. R.
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Larsson, D. G. J ...
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McEwen, S. A.
-
Ryan, J. J.
-
Schonfeld, J.
-
Silley, P.
-
Snape, J. R.
-
Van den Eede, C.
-
Topp, E.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
- Artiklar i publikationen
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Environmental He ...
- Av lärosätet
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Göteborgs universitet