SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Ashbolt N. J.)
 

Search: WFRF:(Ashbolt N. J.) > (2010-2013) > Human Health Risk A...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Ashbolt, N. J. (author)

Human Health Risk Assessment (HHRA) for Environmental Development and Transfer of Antibiotic Resistance

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • Environmental Health Perspectives,2013

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/186729
  • https://gup.ub.gu.se/publication/186729URI
  • https://doi.org/10.1289/ehp.1206316DOI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:for swepub-publicationtype

Notes

  • BACKGROUND: Only recently has the environment been clearly implicated in the risk of antibiotic resistance to clinical outcome, but to date there have been few documented approaches to formally assess these risks. OBJECTIVE: We examined possible approaches and sought to identify research needs to enable human health risk assessments (HHRA) that focus on the role of the environment in the failure of anti-biotic treatment caused by antibiotic-resistant pathogens. METHODS: The authors participated in a workshop held 4-8 March 2012 in Quebec, Canada, to define the scope and objectives of an environmental assessment of antibiotic-resistance risks to human health. We focused on key elements of environmental-resistance-development "hot spots," exposure assessment (unrelated to food), and dose response to characterize risks that may improve antibiotic-resistance management options. DISCUSSION: Various novel aspects to traditional risk assessments were identified to enable an assessment of environmental antibiotic resistance. These include a) accounting for an added selective pressure on the environmental resistome that, over time, allows for development of antibiotic-resistant bacteria (ARB); b) identifying and describing rates of horizontal gene transfer (HGT) in the relevant environmental " hot spot" compartments; and c) modifying traditional dose-response approaches to address doses of ARB for various health outcomes and pathways. CONCLUSIONS: We propose that environmental aspects of antibiotic-resistance development be included in the processes of any HHRA addressing ARB. Because of limited available data, a multi-criteria decision analysis approach would be a useful way to undertake an HHRA of environmental antibiotic resistance that informs risk managers.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Amezquita, A. (author)
  • Backhaus, Thomas,1967Gothenburg University,Göteborgs universitet,Institutionen för biologi och miljövetenskap,Department of Biological and Environmental Sciences(Swepub:gu)xbacth (author)
  • Borriello, P. (author)
  • Brandt, K. K. (author)
  • Collignon, P. (author)
  • Coors, A. (author)
  • Finley, R. (author)
  • Gaze, W. H. (author)
  • Heberer, T. (author)
  • Lawrence, J. R. (author)
  • Larsson, D. G. Joakim,1969Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine(Swepub:gu)xlarjo (author)
  • McEwen, S. A. (author)
  • Ryan, J. J. (author)
  • Schonfeld, J. (author)
  • Silley, P. (author)
  • Snape, J. R. (author)
  • Van den Eede, C. (author)
  • Topp, E. (author)
  • Göteborgs universitetInstitutionen för biologi och miljövetenskap (creator_code:org_t)

Related titles

  • In:Environmental Health Perspectives: Environmental Health Perspectives121:9, s. 993-10010091-67651552-9924

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view