The multitalented Mediator complex

• The Mediator complex is needed for regulated transcription of RNA polymerase II (Pol II)-dependent genes. Initially, Mediator was only seen as a protein bridge that conveyed regulatory information from enhancers to the promoter. Later studies have added many other functions to the Mediator repertoire. Indeed, recent findings show that Mediator influences nearly all stages of transcription and coordinates these events with concomitant changes in chromatin organization. We review the multitude of activities associated with Mediator and discuss how this complex coordinates transcription with other cellular events. We also discuss the inherent difficulties associated with in vivo characterization of a coactivator complex that can indirectly affect diverse cellular processes via changes in gene transcription.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Keyword

Mediator

cohesin

chromatin looping

RNA polymerase II

CDK8

non-coding RNA

RNA-POLYMERASE-II

FISSION YEAST CENTROMERES

TRANSCRIPTIONAL

REGULATION

IN-VIVO

CHROMATIN ARCHITECTURE

COACTIVATOR COMPLEX

MODULE

ASSOCIATION

INTERACTION DOMAIN

GENE-EXPRESSION

NONCODING RNAS

Publication and Content Type

ref (subject category)

art (subject category)