Effects of high-fluoride dentifrice (5,000-ppm) on caries-related plaque and salivary variables.

• OBJECTIVES: The aim of the present study was to measure the effects of a 5,000-ppmF toothpaste on caries-related factors in dental plaque and saliva. MATERIALS AND METHODS: A 6-week clinical trial was designed with a total of 34 participants, of which 26 completed the study. The participants were assessed on four visits, 2 weeks apart. Sampling of approximal fluid for fluoride analysis and approximal plaque for organic acid analysis was performed. Chair-side tests were performed to register the lactic acid production rate on the tongue using Clinpro™ Cario L-Pop™, approximal plaque pH using the pH "strip method" and salivary buffer capacity and counts of cariogenic microorganisms using CRT Buffer® and CRT Bacteria®. RESULTS: Six weeks' use of 5,000-ppm fluoridated (F) toothpaste significantly increased the approximal fluid F concentration (p<0.05). There was a significant decrease in lactic acid production rate on the tongue assessed by Clinpro™ (p<0.05). This was accompanied by changes in interproximal plaque acidogenicity, including significant reductions in AUC5.7, AUC6.2 and maximum pH fall and an increase in minimum pH (p<0.05). A significant increase in the salivary buffer capacity and a reduction in the salivary mutans streptococci were observed (p<0.05). CONCLUSION: The present study demonstrates the ability of 5,000-ppm F toothpaste to modify caries-related factors in dental plaque and saliva. CLINICAL RELEVANCE: The 5,000-ppm F toothpaste could be regarded as a possible effective regimen against caries in the near future

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine (hsv//eng)

Nyckelord

Cariogenic microorganisms; Dentifrice; Fluoride; pH; Plaque; Saliva

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)