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Metformin prevents ...
Metformin prevents the development of chronic heart failure in the SHHF rat model.
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Cittadini, Antonio (författare)
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Napoli, Raffaele (författare)
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Monti, Maria Gaia (författare)
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Rea, Domenica (författare)
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Longobardi, Salvatore (författare)
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Netti, Paolo Antonio (författare)
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- Walser, Marion, 1961 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Samà, Mariateresa (författare)
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Aimaretti, Gianluca (författare)
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- Isgaard, Jörgen, 1959 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Saccà, Luigi (författare)
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(creator_code:org_t)
- 2012-03-14
- 2012
- Engelska.
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Ingår i: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 61:4, s. 944-53
- Relaterad länk:
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https://diabetes.dia...
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https://gup.ub.gu.se...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- Insulin resistance is a recently identified mechanism involved in the pathophysiology of chronic heart failure (CHF). We investigated the effects of two insulin-sensitizing drugs (metformin and rosiglitazone) in a genetic model of spontaneously hypertensive, insulin-resistant rats (SHHF). Thirty SHHF rats were randomized into three treatment groups as follows: 1) metformin (100 mg/kg per day), 2) rosiglitazone (2 mg/kg per day), and 3) no drug. Ten Sprague-Dawley rats served as normal controls. At the end of the treatment period (12 months), the cardiac phenotype was characterized by histology, echocardiography, and isolated perfused heart studies. Metformin attenuated left ventricular (LV) remodeling, as shown by reduced LV volumes, wall stress, perivascular fibrosis, and cardiac lipid accumulation. Metformin improved both systolic and diastolic indices as well as myocardial mechanical efficiency, as shown by improved ability to convert metabolic energy into mechanical work. Metformin induced a marked activation of AMP-activated protein kinase, endothelial nitric oxide synthase, and vascular endothelial growth factor and reduced tumor necrosis factor-α expression and myocyte apoptosis. Rosiglitazone did not affect LV remodeling, increased perivascular fibrosis, and promoted further cardiac lipid accumulation. In conclusion, long-term treatment with metformin, but not with rosiglitazone, prevents the development of severe CHF in the SHHF model by a wide-spectrum interaction that involves molecular, structural, functional, and metabolic-energetic mechanisms.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Animals
- Blood Glucose
- Blood Pressure
- Chronic Disease
- Gene Expression Regulation
- drug effects
- Heart Failure
- prevention & control
- Hypoglycemic Agents
- pharmacology
- therapeutic use
- Insulin
- Insulin Resistance
- Metformin
- pharmacology
- therapeutic use
- Rats
- Rats
- Inbred SHR
- Rats
- Sprague-Dawley
- Thiazolidinediones
- pharmacology
- Vascular Endothelial Growth Factor A
- genetics
- metabolism
- Vascular Endothelial Growth Factor Receptor-2
- genetics
- metabolism
- Ventricular Remodeling
- drug effects
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
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Diabetes
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Till lärosätets databas
- Av författaren/redakt...
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Cittadini, Anton ...
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Napoli, Raffaele
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Monti, Maria Gai ...
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Rea, Domenica
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Longobardi, Salv ...
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Netti, Paolo Ant ...
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visa fler...
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Walser, Marion, ...
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Samà, Mariateres ...
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Aimaretti, Gianl ...
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Isgaard, Jörgen, ...
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Saccà, Luigi
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
- Artiklar i publikationen
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Diabetes
- Av lärosätet
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Göteborgs universitet