Small-bowel obstruction and the effects of lidocaine, atropine and hexamethonium on inflammation and fluid losses.

• The profuse fluid losses and morbidity of patients suffering from obstructive ileus are closely related to inflammatory changes in the obstructed bowel wall. Previous experimental studies have shown that use of steroids and NSAIDs can reduce fluid losses in obstructive ileus. In the present study, we investigated the effects of lidocaine on fluid losses since local anesthetics have been shown to possess wide and potent anti-inflammatory properties. Hexamethonium and atropine were used to study the importance of the autonomic nervous system in bowel obstruction.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)

Nyckelord

Administration

Topical

Anesthetics

Local

therapeutic use

Animals

Anti-Inflammatory Agents

therapeutic use

Atropine

therapeutic use

Coloring Agents

diagnostic use

Dehydration

physiopathology

prevention & control

Enteritis

drug therapy

physiopathology

prevention & control

Evans Blue

diagnostic use

Extravasation of Diagnostic and Therapeutic Materials

Ganglionic Blockers

therapeutic use

Hexamethonium

therapeutic use

Injections

Intravenous

Intestinal Absorption

Intestinal Mucosa

drug effects

secretion

Intestinal Obstruction

drug therapy

physiopathology

prevention & control

Intestinal Secretions

drug effects

metabolism

Jejunal Diseases

drug therapy

physiopathology

prevention & control

Jejunum

drug effects

secretion

Lidocaine

therapeutic use

Male

Muscarinic Antagonists

therapeutic use

Rats

Rats

Sprague-Dawley

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)