Usefulness of Plasmodium falciparum-specific rapid diagnostic tests for assessment of parasite clearance and detection of recurrent infections after artemisinin-based combination therapy.

Rapid diagnostic test (RDT) is an important tool for parasite-based malaria diagnosis. High specificity of RDTs to distinguish an active Plasmodium falciparum infection from residual antigens from a previous infection is crucial in endemic areas where residents are repeatedly exposed to malaria. The efficiency of two RDTs based on histidine-rich protein 2 (HRP2) and lactate dehydrogenase (LDH) antigens were studied and compared with two microscopy techniques (Giemsa and acridine orange-stained blood smears) and real-time polymerase chain reaction (PCR) for assessment of initial clearance and detection of recurrent P. falciparum infections after artemisinin-based combination therapy (ACT) in a moderately high endemic area of rural Tanzania.

Mubi, MarycelinaKarolinska Institutet (author)
Morris, UlrikaKarolinska Institutet (author)
Petzold, Max,1973Gothenburg University,Göteborgs universitet,Akademistatistik,Centre for Applied Biostatistics(Swepub:gu)xpemax (author)
Ngasala, Billy E (author)
Premji, Zul (author)
Björkman, AndersKarolinska Institutet (author)
Mårtensson, AndreasKarolinska Institutet (author)
Karolinska InstitutetAkademistatistik (creator_code:org_t)

By the author/editor: Aydin-Schmidt, B ...; Mubi, Marycelina; Morris, Ulrika; Petzold, Max, 19 ...; Ngasala, Billy E; Premji, Zul; show more...; Björkman, Anders; Mårtensson, Andr ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

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