Motor imagery in bipolar depression with slowed movement.

• We hypothesized that motor retardation in bipolar depression is mediated by disruption of the pre-executive stages of motor production. We used functional magnetic resonance imaging to investigate neural activity during motor imagery and motor execution to elucidate whether brain regions that mediate planning, preparation, and control of movement are activated differently in subjects with bipolar depression (n = 9) compared with healthy controls (n = 12). We found significant between-group differences. During motor imagery, the patients activated the posterior medial parietal cortex, the posterior cingulate cortex, the premotor cortex, the prefrontal cortex, and the frontal poles more than the controls did. Activation in the brain areas involved in motor selection, planning, and preparation was altered. In addition, limbic and prefrontal regions associated with self-reference and the default mode network were altered during motor imagery in bipolar depression with motor retardation.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Keyword

Adult

Aged

Bipolar Disorder

complications

physiopathology

Cerebrum

physiology

physiopathology

Female

Functional Neuroimaging

instrumentation

methods

Gyrus Cinguli

physiology

physiopathology

Humans

Limbic System

physiology

physiopathology

Magnetic Resonance Imaging

instrumentation

methods

Male

Middle Aged

Motor Cortex

physiology

physiopathology

Movement

physiology

Movement Disorders

diagnosis

etiology

physiopathology

Parietal Lobe

physiology

physiopathology

Prefrontal Cortex

physiology

physiopathology

Publication and Content Type

ref (subject category)

art (subject category)