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A Generally Applica...
A Generally Applicable Translational Strategy Identifies S100A4 as a Candidate Gene in Allergy
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- Bruhn, Sören (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet
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- Fang, Yu (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology,Guiyang Medical Coll, Peoples R China University of Gothenburg, Sweden
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- Barrenäs, Fredrik (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet
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- Gustafsson, Mika (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet
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- Zhang, Huan (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet
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- Konstantinell, A. (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet
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- Kronke, A. (author)
- Cenix BioScience GmbH, Germany
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- Sonnichsen, B. (author)
- Cenix BioScience GmbH, Germany
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- Bresnick, A. (author)
- Albert Einstein Coll Med, NY 10461 USA
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- Dulyaninova, N. (author)
- Albert Einstein Coll Med, NY 10461 USA
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- Wang, Hui (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet
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- Zhao, Y. L. (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet
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- Klingelhofer, J. (author)
- University of Copenhagen, Denmark
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- Ambartsumian, N. (author)
- University of Copenhagen, Denmark
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- Beck, M. K. (author)
- Technical University of Denmark, Denmark
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- Nestor, Colm (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet
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- Bona, E. (author)
- Boras Hospital, Sweden
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- Xiang, Zou (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology,University of Gothenburg, Sweden
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- Benson, Mikael (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Allergicentrum US,Barn- och ungdomskliniken i Linköping
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(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2014
- 2014
- English.
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In: Science Translational Medicine. - : American Association for the Advancement of Science (AAAS). - 1946-6234 .- 1946-6242. ; 6:218
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https://liu.diva-por... (primary) (Raw object)
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Abstract
Subject headings
Close
- The identification of diagnostic markers and therapeutic candidate genes in common diseases is complicated by the involvement of thousands of genes. We hypothesized that genes co-regulated with a key gene in allergy, IL13, would form a module that could help to identify candidate genes. We identified a T helper 2 (T(H)2) cell module by small interfering RNA-mediated knockdown of 25 putative IL13-regulating transcription factors followed by expression profiling. The module contained candidate genes whose diagnostic potential was supported by clinical studies. Functional studies of human TH2 cells as well as mouse models of allergy showed that deletion of one of the genes, S100A4, resulted in decreased signs of allergy including TH2 cell activation, humoral immunity, and infiltration of effector cells. Specifically, dendritic cells required S100A4 for activating T cells. Treatment with an anti-S100A4 antibody resulted in decreased signs of allergy in the mouse model as well as in allergen-challenged T cells from allergic patients. This strategy, which may be generally applicable to complex diseases, identified and validated an important diagnostic and therapeutic candidate gene in allergy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Keyword
- NETWORK-BASED ANALYSIS
- T-CELLS
- ACTIVATOR PROTEIN-1
- ATOPIC-DERMATITIS
- MAST-CELLS
- EXPRESSION
- DISEASE
- ASTHMA
- CANCER
- INTERLEUKIN-13
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Bruhn, Sören
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Fang, Yu
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Barrenäs, Fredri ...
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Gustafsson, Mika
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Zhang, Huan
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Konstantinell, A ...
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show more...
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Kronke, A.
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Sonnichsen, B.
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Bresnick, A.
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Dulyaninova, N.
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Wang, Hui
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Zhao, Y. L.
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Klingelhofer, J.
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Ambartsumian, N.
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Beck, M. K.
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Nestor, Colm
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Bona, E.
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Xiang, Zou
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Benson, Mikael
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
- Articles in the publication
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Science Translat ...
- By the university
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University of Gothenburg
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Linköping University