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The regulation of m...
The regulation of maturation promoting factor during prophase I arrest and meiotic entry in mammalian oocytes
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- Adhikari, Deepak (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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- Liu, Kui (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- English.
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In: Molecular and Cellular Endocrinology. - : Elsevier BV. - 0303-7207. ; 382:1, s. 480-487
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Abstract
Subject headings
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- Mammalian oocytes arrest at prophase of meiosis I at around birth and they remain arrested at this stage until puberty when the preovulatory surge of luteinizing hormone (LH) causes ovulation. Prophase I arrest in the immature oocyte results from the maintenance of low activity of maturation promoting factor (MPF), which consists of a catalytic subunit (CDK1) and regulatory subunit (cyclin B1). Phosphorylation-mediated inactivation of CDK1 and constant degradation of cyclin B1 keep MPF activity low during prophase I arrest. LH-mediated signaling manipulates a vast array of molecules to activate CDK1. Active CDK1 not only phosphorylates different meiotic phosphoproteins during the resumption of meiosis but also inhibits their rapid dephosphorylation by inhibiting the activities of CDK1 antagonizing protein phosphatases (PPs). In this way, CDK1 both phosphorylates its substrates and protects them from being dephosphorylated. Accumulating evidence suggests thatthe net MPF activity that drives the resumption of meiosis in oocytes depends on the activation status of CDK1 antagonizing PPs. This review aims to provide a summary of the current understanding of the signaling pathways involved in regulating MPF activity during prophase I arrest and reentry into meiosis of mammalian oocytes. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Oocyte
- Meiosis resumption
- MPF
- Protein phosphatases
- PROTEIN-KINASE-A
- GERMINAL VESICLE BREAKDOWN
- PORCINE GROWING OOCYTES
- TO-CELL COMMUNICATION
- M-PHASE ENTRY
- MOUSE OOCYTES
- GREATWALL KINASE
- LUTEINIZING-HORMONE
- OKADAIC ACID
- PHOSPHORYLATION SITES
Publication and Content Type
- ref (subject category)
- art (subject category)
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