An enzymatic chromatin switch that directs formation of active brown fat

• How is the recruitment of brown adipocytes regulated? Ohno et al. (2013) show that the euchromatic histone-lysine N-metyltransferase 1 (EHMT1) is essential for the specification of the brown adipocyte fate, a finding with important implications for the pathophysiology of obesity and obesity-related maladies. © 2014 Elsevier Inc.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Nyckelord

cre recombinase

early b lymphocyte factor 2

euchromatic histonelysine n metyltransferase 1

growth promotor

myogenic factor 5

peroxisome proliferator activated receptor gamma

protein methyltransferase

protein precursor

unclassified drug

brown adipose tissue

cell differentiation

cell fate

cell transformation

cold exposure

DNA methylation

enzymatic chromatin switch

enzyme activity

gene control

glucose tolerance

human

long term exposure

mitochondrial respiration

muscle

obesity

priority journal

review

white adipose tissue

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)