(WFRF:(Pettersson Ulrika))
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Acute sleep deprivation increases serum levels of neuron-specific enolase (NSE) and S100 calcium binding protein B (S-100B) in healthy young men.
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- Benedict, Christian (author)
- Uppsala universitet,Funktionell farmakologi
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- Cedernaes, Jonathan (author)
- Uppsala universitet,Funktionell farmakologi
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- Giedraitis, Vilmantas (author)
- Uppsala universitet,Geriatrik,Molekylär geriatrik
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- (creator_code:org_t)
- Oxford University Press (OUP), 2014
- 2014
- English.
- In: Sleep. - : Oxford University Press (OUP). - 1550-9109 .- 0161-8105. ; 37:1, s. 195-8
- Journal article (peer-reviewed)
Abstract
Subject headings
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- To investigate whether total sleep deprivation (TSD) affects circulating concentrations of neuron-specific enolase (NSE) and S100 calcium binding protein B (S-100B) in humans. These factors are usually found in the cytoplasm of neurons and glia cells. Increasing concentrations of these factors in blood may be therefore indicative for either neuronal damage, impaired blood brain barrier function, or both. In addition, amyloid β (Aβ) peptides 1-42 and 1-40 were measured in plasma to calculate their ratio. A reduced plasma ratio of Aβ peptides 1-42 to 1-40 is considered an indirect measure of increased deposition of Aβ 1-42 peptide in the brain.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
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- ref (subject category)
- art (subject category)
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- Sleep
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- University of Gothenburg
- Uppsala University
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