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  • Lehmann, SKarolinska Institutet,Karolinska University Hospital (author)

Continuing high early death rate in acute promyelocytic leukemia: a population-based report from the Swedish Adult Acute Leukemia Registry.

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • 2011-04-19
  • Springer Science and Business Media LLC,2011

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/196297
  • https://gup.ub.gu.se/publication/196297URI
  • https://doi.org/10.1038/leu.2011.78DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-22581URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-44921URI
  • https://lup.lub.lu.se/record/2093987URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-164765URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:122932827URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-69804URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Our knowledge about acute promyelocytic leukemia (APL) patients is mainly based on data from clinical trials, whereas population-based information is scarce. We studied APL patients diagnosed between 1997 and 2006 in the population-based Swedish Adult Acute Leukemia Registry. Of a total of 3897 acute leukemia cases, 3205 (82%) had non-APL acute myeloid leukemia (AML) and 105 (2.7%) had APL. The incidence of APL was 0.145 per 100,000 inhabitants per year. The median age at the time of diagnosis was 54 years; 62% were female and 38% male. Among younger APL patients, female sex predominated (89% of patients <40 years). Of the 105 APL patients, 30 (29%) died within 30 days (that is, early death (ED)) (median 4 days) and 28 (26%) within 14 days from diagnosis. In all, 41% of the EDs were due to hemorrhage; 35% of ED patients never received all-trans-retinoic acid treatment. ED rates increased with age but more clearly with poor performance status. ED was also associated with high white blood cells, lactate dehydrogenase, creatinine, C-reactive protein and low platelet count. Of non-ED patients, 97% achieved complete remission of which 16% subsequently relapsed. In total, 62% are still alive at 6.4 years median follow-up. We conclude that ED rates remain very high in an unselected APL population.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Ravn, AKarolinska Institutet,Karolinska University Hospital (author)
  • Carlsson, LKarolinska University Hospital (author)
  • Antunovic, PetarLinköpings universitet,Hälsouniversitetet,Kirurgi(Swepub:liu)petan27 (author)
  • Deneberg, SKarolinska Institutet,Karolinska University Hospital,Sahlgrens University Hospital (author)
  • Möllgård, LKarolinska Institutet,Karolinska University Hospital (author)
  • Derolf, A RangertKarolinska University Hospital (author)
  • Stockelberg, Dick,1950Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine(Swepub:gu)xstodi (author)
  • Tidefelt, Ulf,1951-Örebro universitet,Institutionen för hälsovetenskap och medicin,Orebro University Hospital(Swepub:oru)uftt (author)
  • Wahlin, AndersUmeå universitet,Institutionen för strålningsvetenskaper,Umea University(Swepub:umu)anwa0027 (author)
  • Wennström, LovisaGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine,Sahlgrens University Hospital (author)
  • Höglund, MUppsala universitet,Medicin,Hematologi,Acad Hospital, Uppsala (author)
  • Juliusson, GunnarLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skane University Hospital(Swepub:lu)stem-gju (author)
  • Ravn, S (author)
  • Högberg, M (author)
  • Karolinska InstitutetKarolinska University Hospital (creator_code:org_t)

Related titles

  • In:Leukemia: Springer Science and Business Media LLC25:7, s. 1128-341476-55510887-6924

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