Multivariate evaluation of doxorubicin surface-enhanced Raman spectra.

• Multivariate evaluation of surface-enhanced Raman spectra of doxorubicin in plasma was performed. In a principal component analysis (PCA) all spectral features were modelled into three principal components. The major variation of the data was shown to be the variation of doxorubicin Raman signal together with the doxorubicin fluorescence, whereas the variation due to plasma was of minor importance. It was also shown that the surface-enhanced Raman scattering (SERS) measurements were independent on such factors as measurement occasion and silver colloids. The presented results show that with some improvements, quantification of doxorubicin directly in plasma could be possible.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Andra medicinska och farmaceutiska grundvetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Other Basic Medicine (hsv//eng)

Nyckelord

Animals

Antibiotics

Antineoplastic

blood

chemistry

Cattle

Doxorubicin

blood

chemistry

Multivariate Analysis

Plasma

chemistry

Principal Component Analysis

Signal Processing

Computer-Assisted

Spectrum Analysis

Raman

Multivariate Analysis

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)