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Cytokine release du...
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Adrian, Katrin,1966Gothenburg University,Göteborgs universitet,Institutionen för lingvistik,Department of Linguistics
(author)
Cytokine release during long-term extracorporeal circulation in an experimental model.
- Article/chapterEnglish1998
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/197824
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https://gup.ub.gu.se/publication/197824URI
Supplementary language notes
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The objective of this study was to determine the degree of leukocyte activation, as measured by cytokine release, in circulating blood during experimental extracorporeal circulation. Complete in vitro extracorporeal membrane oxygenation (ECMO) circuits were used, and 9 experiments were performed. Whole blood stored at 37 degrees C was used as the control. Blood samples were withdrawn before the start of perfusion and at 24 h of perfusion. Statistically significant releases of interleukin (IL)-1beta, IL-8, and IL-1 receptor antagonist were observed in the perfusion circuits compared to both the control blood and baseline values. Also, increases in plasma tumor necrosis factor (TNF)alpha and IL-6 were seen after 24 h of perfusion although these changes did not reach statistical significance. These results indicate that extracorporeal circulation induced leukocyte activation and cytokine release. These reactions might, as an additional trauma, deteriorate the situation in an already severely ill patient. A search for methods to counteract this untoward activation seems warranted.
Subject headings and genre
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MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
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MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
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Adult
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Anticoagulants
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blood
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Blood Cell Count
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Chemotaxis
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Leukocyte
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physiology
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Critical Illness
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Cytokines
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blood
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Equipment Design
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Extracorporeal Circulation
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instrumentation
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methods
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Hemoglobins
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analysis
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Heparin
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blood
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Humans
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Interleukin-1
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blood
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Interleukin-6
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blood
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Interleukin-8
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blood
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Leukocyte Count
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Leukocytes
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physiology
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Neutrophils
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cytology
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Oxygenators
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Platelet Count
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Receptors
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Interleukin-1
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antagonists & inhibitors
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Tumor Necrosis Factor-alpha
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analysis
Added entries (persons, corporate bodies, meetings, titles ...)
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Mellgren, Karin,1962Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics(Swepub:gu)xmellk
(author)
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Skogby, Maria,1965Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics
(author)
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Friberg, Lars-Göran,1945
(author)
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Mellgren, G
(author)
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Wadenvik, Hans,1955Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xwadha
(author)
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Göteborgs universitetInstitutionen för lingvistik
(creator_code:org_t)
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In:Artificial organs22:10, s. 859-630160-564X
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