Cytokine release during long-term extracorporeal circulation in an experimental model.

Adrian, Katrin,1966Gothenburg University,Göteborgs universitet,Institutionen för lingvistik,Department of Linguistics (författare)

The objective of this study was to determine the degree of leukocyte activation, as measured by cytokine release, in circulating blood during experimental extracorporeal circulation. Complete in vitro extracorporeal membrane oxygenation (ECMO) circuits were used, and 9 experiments were performed. Whole blood stored at 37 degrees C was used as the control. Blood samples were withdrawn before the start of perfusion and at 24 h of perfusion. Statistically significant releases of interleukin (IL)-1beta, IL-8, and IL-1 receptor antagonist were observed in the perfusion circuits compared to both the control blood and baseline values. Also, increases in plasma tumor necrosis factor (TNF)alpha and IL-6 were seen after 24 h of perfusion although these changes did not reach statistical significance. These results indicate that extracorporeal circulation induced leukocyte activation and cytokine release. These reactions might, as an additional trauma, deteriorate the situation in an already severely ill patient. A search for methods to counteract this untoward activation seems warranted.

Mellgren, Karin,1962Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics(Swepub:gu)xmellk (författare)
Skogby, Maria,1965Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics (författare)
Friberg, Lars-Göran,1945 (författare)
Mellgren, G (författare)
Wadenvik, Hans,1955Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xwadha (författare)
Göteborgs universitetInstitutionen för lingvistik (creator_code:org_t)

Av författaren/redakt...: Adrian, Katrin, ...; Mellgren, Karin, ...; Skogby, Maria, 1 ...; Friberg, Lars-Gö ...; Mellgren, G; Wadenvik, Hans, ...

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