Nitric oxide in the oxygenator sweep gas reduces platelet activation during experimental perfusion.

• Hemorrhage is a major complication experienced in 10% to 35% of neonates treated with extracorporeal life support (ECLS). The increased bleeding tendency is partly due to an ECLS-induced thrombocytopenia and impaired platelet function. In the present study, we evaluated the effect of nitric oxide on the ECLS-induced platelet consumption and activation.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

Analysis of Variance

Blood Platelets

chemistry

drug effects

Dose-Response Relationship

Drug

Extracorporeal Membrane Oxygenation

instrumentation

methods

statistics & numerical data

Humans

Nitric Oxide

administration & dosage

Plasma

chemistry

drug effects

Platelet Activation

drug effects

Time Factors

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)