In vitro platelet function in infantile autism.

It has previously been demonstrated that patients with infantile autism demonstrate impaired in vivo platelet behaviour. Therefore, in 14 children (13 boys and 1 girl) with infantile autism (aged 2-14, mean 6 years) and 12 healthy control boys (aged 6-15, mean 11 years) we studied in vitro platelet reactivity using ADP- and collagen-induced platelet aggregation. In each child a total of 7 different final concentrations of ADP and 4 different concentrations of collagen were employed. At all concentrations of ADP and collagen used the autistic children consistently exhibited diminished platelet aggregability; the differences, however, did not reach statistical significance. Therefore a wider panel of in vitro tests is apparently required and a larger group of patients be studied to help elucidate the functional/metabolic platelet defect met in infantile autism.

Denfors, I (author)
Kutti, JackGothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine(Swepub:gu)xkutja (author)
Wadenvik, Hans,1955Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine(Swepub:gu)xwadha (author)
Göteborgs universitetMedicinska institutionen (creator_code:org_t)

By the author/editor: Safai-Kutti, Soo ...; Denfors, I; Kutti, Jack; Wadenvik, Hans, ...

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