Influence of refill adherence method when comparing level of adherence for different dosing regimens

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MARC

Jönsson, Anna KÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för läkemedelsforskning,Hälsouniversitetet,Klinisk farmakologi (author)

Influence of refill adherence method when comparing level of adherence for different dosing regimens

Article/chapterEnglish2014

Publisher, publication year, extent ...

2014-02-13
Springer Science and Business Media LLC,2014

Numbers

LIBRIS-ID:oai:gup.ub.gu.se/198826
https://gup.ub.gu.se/publication/198826URI
https://doi.org/10.1007/s00228-014-1649-2DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-106673URI

Supplementary language notes

Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

To examine the impact of two methods when estimating refill adherence in patients using bisphosphonates with different dosing regimens. In the Swedish Prescribed Drug Register, 18,203 new users of bisphosphonates aged 18-85 years were identified between 1 July 2006 and 30 June 2007 and followed for a maximum of 2 years. The patients were categorised based on dosing regimen: one tablet daily, one tablet weekly, switching between these regimens, and other regimens. Refill adherence was estimated with Continuous measure of Medication Acquisition (CMA, adherent if CMA a parts per thousand yenaEuro parts per thousand 80 %) and the maximum gap method (adherent if gaps < 45 days). Differences in adherence between patients in the groups were assessed with logistic regression models controlling for confounding factors. The proportion of patients classified as adherent was higher using CMA compared with patients classified as adherent using the maximum gap method. Patients on one tablet weekly had significantly lower adherence compared with patients on one tablet daily in the main analyses of both methods (the maximum gap method: 73 % vs. 80 %; adjusted OR = 0.71; 95 % CI 0.57-0.89 and CMA: 84 % vs. 88 %, adjusted OR = 0.75; 95 % CI 0.57-0.99). Patients using the other two dosing regimens had significantly lower adherence compared with patients on one tablet daily using both methods. Choice of method has an impact on the estimates of refill adherence to bisphosphonates. Patients on one tablet weekly dosing had lower adherence compared with patients on one tablet daily dosing using both methods.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Annan medicin och hälsovetenskap hsv//swe
MEDICAL AND HEALTH SCIENCES Other Medical and Health Sciences hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Samhällsfarmaci och klinisk farmaci hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Social and Clinical Pharmacy hsv//eng
Medication adherence
Swedish Prescribed Drug Register
Dosing regimen
Bisphosphonates
MEDICATION ADHERENCE
PHARMACOEPIDEMIOLOGIC RESEARCH
PRESCRIPTION SIZE
OSTEOPOROSIS
PERSISTENCE
BISPHOSPHONATES
DATABASES
VALIDITY
RECORDS
DRUGS
EINER JF
1993
JOURNAL OF GENERAL INTERNAL MEDICINE
V8
P306
Medication adherence; Swedish Prescribed Drug Register; Dosing regimen; Bisphosphonates
MEDICINE

Added entries (persons, corporate bodies, meetings, titles ...)

Schiöler, Linus,1977Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,University of Gothenburg, Sweden(Swepub:gu)xschli (author)
Lesén, Eva,1982Nordic Health Econ AB, Sweden(Swepub:gu)xlesev (author)
Andersson Sundell, Karolina,1978Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,University of Gothenburg, Sweden Nordic School Public Heatlh, Sweden(Swepub:gu)xakarj (author)
Mårdby, Ann-Charlotte,1976Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,University of Gothenburg, Sweden Sahlgrens University Hospital, Sweden(Swepub:gu)xmaann (author)
Linköpings universitetAvdelningen för läkemedelsforskning (creator_code:org_t)

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In:European Journal of Clinical Pharmacology: Springer Science and Business Media LLC70:5, s. 589-5970031-69701432-1041

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