Image-based 3D modeling study of the influence of vessel density and blood hemoglobin concentration on tumor oxygenation and response to irradiation.

• Hypoxia is one of the most important factors influencing clinical outcome after radiotherapy. Improved knowledge of factors affecting the levels and distribution of oxygen within a tumor is needed. The authors constructed a theoretical 3D model based on histological images to analyze the influence of vessel density and hemoglobin (Hb) concentration on the response to irradiation.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

biochemistry

biological effects of radiation

blood

blood vessels

cellular biophysics

diffusion

Green's function methods

medical disorders

medical image processing

oxygen

radiation therapy

tumours

tumor control probability

dosimetry

modeling

hypoxia

radiotherapy

Animals

Blood Vessels/metabolism

Hemoglobins/metabolism

Insulinoma/blood

Mice

Models, Biological

Oxygen/metabolism

Pancreatic Neoplasms/blood

Treatment Outcome

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)