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A Novel Fibrosis In...
A Novel Fibrosis Index Comprising a Non-Cholesterol Sterol Accurately Predicts HCV-Related Liver Cirrhosis
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- Ydreborg, Magdalena, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg
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- Lisovskaja, Vera, 1984 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology
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- Lagging, Martin, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg
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Christensen, P. B. (author)
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- Langeland, N. (author)
- Universitetet i Bergen,University of Bergen
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- Buhl, M. R. (author)
- Århus Universitet,Aarhus University
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Pedersen, C. (author)
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- Morch, K. (author)
- Universitetet i Bergen,University of Bergen
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- Wejstål, Rune, 1952 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg
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- Norkrans, Gunnar, 1944 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg
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- Lindh, Magnus, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg
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- Farkkila, M. (author)
- Helsingin Yliopisto,University of Helsinki
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- Westin, Johan, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg
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(creator_code:org_t)
- 2014-04-03
- 2014
- English.
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In: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 9:4
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Abstract
Subject headings
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- Diagnosis of liver cirrhosis is essential in the management of chronic hepatitis C virus (HCV) infection. Liver biopsy is invasive and thus entails a risk of complications as well as a potential risk of sampling error. Therefore, non-invasive diagnostic tools are preferential. The aim of the present study was to create a model for accurate prediction of liver cirrhosis based on patient characteristics and biomarkers of liver fibrosis, including a panel of non-cholesterol sterols reflecting cholesterol synthesis and absorption and secretion. We evaluated variables with potential predictive significance for liver fibrosis in 278 patients originally included in a multicenter phase III treatment trial for chronic HCV infection. A stepwise multivariate logistic model selection was performed with liver cirrhosis, defined as Ishak fibrosis stage 5-6, as the outcome variable. A new index, referred to as Nordic Liver Index (NoLI) in the paper, was based on the model:Log-odds (predicting cirrhosis) =-12.17+ (agex0.11) + (BMI (kg/m(2))x0.23) + (D-7-lathosterol (mu g/100 mg cholesterol)x(-0.013)) + (Platelet count (x10(9)/L)x(-0.018)) + (Prothrombin-INRx3.69). The area under the ROC curve (AUROC) for prediction of cirrhosis was 0.91 (95% CI 0.86-0.96). The index was validated in a separate cohort of 83 patients and the AUROC for this cohort was similar (0.90; 95% CI: 0.82-0.98). In conclusion, the new index may complement other methods in diagnosing cirrhosis in patients with chronic HCV infection.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- CHRONIC HEPATITIS-C
- PRIMARY BILIARY-CIRRHOSIS
- STANDARD LABORATORY
- TESTS
- CHRONIC VIRAL-HEPATITIS
- TRANSIENT ELASTOGRAPHY
- VIRUS-INFECTION
- INSULIN-RESISTANCE
- SERUM MARKERS
- STEATOSIS
- TRANSPLANTATION
- ETTINEN TA
- 1988
- JOURNAL OF LIPID RESEARCH
- V29
- P43
- ETTINEN TA
- 1990
- AMERICAN JOURNAL OF EPIDEMIOLOGY
- V131
- P20
- 1988
Publication and Content Type
- ref (subject category)
- art (subject category)
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Ydreborg, Magdal ...
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Lisovskaja, Vera ...
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Lagging, Martin, ...
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Christensen, P. ...
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Langeland, N.
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Buhl, M. R.
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Pedersen, C.
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Morch, K.
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Wejstål, Rune, 1 ...
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Norkrans, Gunnar ...
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Lindh, Magnus, 1 ...
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Farkkila, M.
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Westin, Johan, 1 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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Plos One
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University of Gothenburg
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Chalmers University of Technology