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Advancing research ...
Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria.
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Dubois, Bruno (author)
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Feldman, Howard H (author)
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Jacova, Claudia (author)
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Hampel, Harald (author)
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Molinuevo, José Luis (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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DeKosky, Steven T (author)
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Gauthier, Serge (author)
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Selkoe, Dennis (author)
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Bateman, Randall (author)
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Cappa, Stefano (author)
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Crutch, Sebastian (author)
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Engelborghs, Sebastiaan (author)
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Frisoni, Giovanni B (author)
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Fox, Nick C (author)
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Galasko, Douglas (author)
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Habert, Marie-Odile (author)
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Jicha, Gregory A (author)
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- Nordberg, Agneta (author)
- Karolinska Institutet
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Pasquier, Florence (author)
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Rabinovici, Gil (author)
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Robert, Philippe (author)
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Rowe, Christopher (author)
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Salloway, Stephen (author)
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Sarazin, Marie (author)
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Epelbaum, Stéphane (author)
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de Souza, Leonardo C (author)
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Vellas, Bruno (author)
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Visser, Pieter J (author)
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Schneider, Lon (author)
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Stern, Yaakov (author)
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Scheltens, Philip (author)
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Cummings, Jeffrey L (author)
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(creator_code:org_t)
- 2014
- 2014
- English.
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In: Lancet neurology. - 1474-4465. ; 13:6, s. 614-29
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- In the past 8 years, both the International Working Group (IWG) and the US National Institute on Aging-Alzheimer's Association have contributed criteria for the diagnosis of Alzheimer's disease (AD) that better define clinical phenotypes and integrate biomarkers into the diagnostic process, covering the full staging of the disease. This Position Paper considers the strengths and limitations of the IWG research diagnostic criteria and proposes advances to improve the diagnostic framework. On the basis of these refinements, the diagnosis of AD can be simplified, requiring the presence of an appropriate clinical AD phenotype (typical or atypical) and a pathophysiological biomarker consistent with the presence of Alzheimer's pathology. We propose that downstream topographical biomarkers of the disease, such as volumetric MRI and fluorodeoxyglucose PET, might better serve in the measurement and monitoring of the course of disease. This paper also elaborates on the specific diagnostic criteria for atypical forms of AD, for mixed AD, and for the preclinical states of AD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Alzheimer Disease
- diagnosis
- genetics
- physiopathology
- Biological Markers
- analysis
- chemistry
- Humans
- International Cooperation
- Phenotype
- Practice Guidelines as Topic
- standards
- Societies
- Medical
- standards
Publication and Content Type
- ref (subject category)
- for (subject category)
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- By the author/editor
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Dubois, Bruno
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Feldman, Howard ...
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Jacova, Claudia
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Hampel, Harald
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Molinuevo, José ...
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Blennow, Kaj, 19 ...
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show more...
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DeKosky, Steven ...
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Gauthier, Serge
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Selkoe, Dennis
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Bateman, Randall
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Cappa, Stefano
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Crutch, Sebastia ...
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Engelborghs, Seb ...
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Frisoni, Giovann ...
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Fox, Nick C
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Galasko, Douglas
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Habert, Marie-Od ...
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Jicha, Gregory A
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Nordberg, Agneta
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Pasquier, Floren ...
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Rabinovici, Gil
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Robert, Philippe
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Rowe, Christophe ...
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Salloway, Stephe ...
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Sarazin, Marie
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Epelbaum, Stépha ...
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de Souza, Leonar ...
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Vellas, Bruno
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Visser, Pieter J
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Schneider, Lon
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Stern, Yaakov
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Scheltens, Phili ...
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Cummings, Jeffre ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Lancet neurology
- By the university
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University of Gothenburg
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Karolinska Institutet