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Low-grade albuminur...
Low-grade albuminuria and the incidence of heart failure in a community-based cohort of elderly men
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- Ingelsson, Erik (författare)
- Uppsala universitet,Geriatrik,Geriatrics
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- Sundström, Johan (författare)
- Uppsala universitet,Geriatrik,Institutionen för medicinska vetenskaper,Geriatrics
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- Lind, Lars (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Risérus, Ulf (författare)
- Uppsala universitet,Geriatrik,Geriatrics
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- Larsson, Anders (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Basu, Samar (författare)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Clinical Nutrition
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- Ärnlöv, Johan (författare)
- Uppsala universitet,Geriatrik,Geriatrics
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(creator_code:org_t)
- 2007-03-06
- 2007
- Engelska.
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Ingår i: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 28:14, s. 1739-1745
- Relaterad länk:
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http://www.ncbi.nlm....
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Aims To investigate associations of urinary albumin excretion rate (UAER) and heart failure (HF) incidence in a community-based sample. Methods and results In a prospective study of 70-year-old men free from HF at baseline (n = 1106), UAER (from timed overnight samples) was analysed with established risk factors for HF [acute MI before baseline, acute MI during follow-up (modelled as a time-dependent covariate), hypertension, diabetes, left ventricular hypertrophy, smoking, body mass index, and glomerular filtration rate] and more recently described risk factors [high-sensitive C-reactive protein and insulin sensitivity (clamp glucose disposal rate)] as predictors of HF incidence. Ninety-eight participants developed HF during a median follow-up of 9.0 years. In Cox proportional hazards models adjusted for established and novel risk factors for HF, a 1 SD increase in log UAER increased the risk of HF in individuals without anti-hypertensive treatment (hazard ratio 1.49; 95% CI 1.13–1.98; P = 0.005). Furthermore, UAER remained an independent predictor of HF, also in participants without diabetes at baseline or myocardial infarction at baseline or during follow-up. There were no significant associations between UAER and HF incidence in individuals with anti-hypertensive treatment. Conclusion Our observations support the notion that low-grade albuminuria is a marker for subclinical cardiovascular damage that predisposes to future HF in the community.
Nyckelord
- Heart failure
- Albuminuria
- Kidney failure
- Epidemiology
- Risk factors
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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