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Metoprolol Reduces ...
Metoprolol Reduces Proinflammatory Cytokines and Atherosclerosis in ApoE(-/-) Mice
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- Ulleryd, Marcus A (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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- Bernberg, Evelina, 1981 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Yang, Li Jin (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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- Bergström, Göran, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Johansson, Maria E, 1977 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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(creator_code:org_t)
- Hindawi Limited, 2014
- 2014
- Engelska.
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Ingår i: Biomed Research International. - : Hindawi Limited. - 2314-6133 .- 2314-6141.
- Relaterad länk:
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http://downloads.hin...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- A few studies in animals and humans suggest that metoprolol (beta 1-selective adrenoceptor antagonist) may have a direct antiatherosclerotic effect. However, the mechanism behind this protective effect has not been established. The aim of the present study was to evaluate the effect of metoprolol on development of atherosclerosis in ApoE(-/-) mice and investigate its effect on the release of proinflammatory cytokines. Male ApoE(-/-) mice were treated with metoprolol (2.5mg/kg/ h) or saline for 11 weeks via osmotic minipumps. Atherosclerosis was assessed in thoracic aorta and aortic root. Total cholesterol levels and Th1/Th2 cytokines were analyzed in serum and macrophage content in lesions by immunohistochemistry. Metoprolol significantly reduced atherosclerotic plaque area in thoracic aorta (P < 0.05 versus Control). Further, metoprolol reduced serum TNF alpha and the chemokine CXCL1 (P < 0.01 versus Control for both) as well as decreasing the macrophage content in the plaques (P < 0.01 versus Control). Total cholesterol levels were not affected. In this study we found that a moderate dose of metoprolol significantly reduced atherosclerotic plaque area in thoracic aorta of ApoE(-/-) mice. Metoprolol also decreased serum levels of proinflammatory cytokines TNF alpha and CXCL1 and macrophage content in the plaques, showing that metoprolol has an anti-inflammatory effect. LAD B, 1988, AMERICAN HEART JOURNAL, V116, P322
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology (hsv//eng)
Nyckelord
- LOWERING ASYMPTOMATIC PLAQUE
- INTIMA-MEDIA THICKNESS
- APOE-DEFICIENT
- MICE
- ACCELERATES ATHEROSCLEROSIS
- PSYCHOSOCIAL STRESS
- CYNOMOLGUS
- MONKEYS
- ANGIOTENSIN-II
- BLOOD-PRESSURE
- BETA-BLOCKADE
- TNF-ALPHA
- Biotechnology & Applied Microbiology
- Medicine
- Research & Experimental
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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