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Association between...
Association between amygdala reactivity and a dopamine transporter gene polymorphism.
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- Bergman, Olle, 1978 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology,Department of Pharmacology, University of Gothenburg, Gothenburg, Sweden
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- Åhs, Fredrik (author)
- Uppsala universitet,Karolinska Institutet,Institutionen för psykologi
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- Furmark, Tomas (author)
- Uppsala universitet,Institutionen för psykologi
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- Appel, Lieuwe (author)
- Uppsala universitet,Enheten för nuklearmedicin och PET
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- Linnman, C (author)
- Uppsala universitet,Institutionen för psykologi
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- Faria, Vanda (author)
- Uppsala universitet,Institutionen för psykologi
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- Bani, M (author)
- GlaxoSmithKline, Medicine ResearchCentre, Verona, Italy,Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA
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- Eriksson, Elias, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology
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- Bettica, P (author)
- GlaxoSmithKline, Medicine ResearchCentre, Verona, Italy
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- Henningsson, Susanne, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology,Department of Pharmacology, University of Gothenburg, Gothenburg, Sweden
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Manuck, S B (author)
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- Ferrell, R E (author)
- Human Genetics, Graduate School of Public Health, University of Pittsburgh,Pittsburgh, PA, USA
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- Nikolova, Y S (author)
- Department of Physiology & Neuroscience and Duke Institute for Genome Science & Policy, Duke University, Durham, NC, USA.
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- Hariri, A R (author)
- Department of Physiology & Neuroscience and Duke Institute for Genome Science & Policy, Duke University, Durham, NC, USA.
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- Fredrikson, Mats (author)
- Uppsala universitet,Institutionen för psykologi
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- Westberg, Lars, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology,Department of Pharmacology, University of Gothenburg, Gothenburg, Sweden
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- Eriksson, Elias, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology
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(creator_code:org_t)
- 2014-08-05
- 2014
- English.
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In: Translational psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 4
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https://gup.ub.gu.se...
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Abstract
Subject headings
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- Essential for detection of relevant external stimuli and for fear processing, the amygdala is under modulatory influence of dopamine (DA). The DA transporter (DAT) is of fundamental importance for the regulation of DA transmission by mediating reuptake inactivation of extracellular DA. This study examined if a common functional variable number tandem repeat polymorphism in the 3' untranslated region of the DAT gene (SLC6A3) influences amygdala function during the processing of aversive emotional stimuli. Amygdala reactivity was examined by comparing regional cerebral blood flow, measured with positron emission tomography and [(15)O]water, during exposure to angry and neutral faces, respectively, in a Swedish sample comprising 32 patients with social anxiety disorder and 17 healthy volunteers. In a separate US sample, comprising 85 healthy volunteers studied with blood oxygen level-dependent functional magnetic resonance imaging, amygdala reactivity was assessed by comparing the activity during exposure to threatening faces and neutral geometric shapes, respectively. In both the Swedish and the US sample, 9-repeat carriers displayed higher amygdala reactivity than 10-repeat homozygotes. The results suggest that this polymorphism contributes to individual variability in amygdala reactivity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- amygdala reactivity
- dopamine transporter
Publication and Content Type
- ref (subject category)
- art (subject category)
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Bergman, Olle, 1 ...
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Åhs, Fredrik
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Furmark, Tomas
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Appel, Lieuwe
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Linnman, C
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Faria, Vanda
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show more...
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Bani, M
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Eriksson, Elias, ...
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Bettica, P
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Henningsson, Sus ...
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Manuck, S B
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Ferrell, R E
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Nikolova, Y S
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Hariri, A R
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Fredrikson, Mats
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Westberg, Lars, ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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MEDICAL AND HEAL ...
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and Basic Medicine
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Translational ps ...
- By the university
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University of Gothenburg
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Mid Sweden University
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Karolinska Institutet
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Uppsala University