The PNPLA3 I148M variant and chronic liver disease: When a genetic mutation meets nutrients

• The isoleucine to methionine substitution at position 148 in the patatin-like phospholipase domain containing 3 protein (PNPLA3; I148M variant, rs738409) is associated with liver fat accumulation and an increased risk of chronic liver disease ranging from hepatitis to hepatocellular carcinoma. This review discusses the interaction between the PNPLA3 I148M variant and obesity/intake of specific nutrients in determining the susceptibility to liver disease. We present the results of several studies showing that obesity or alcohol abuse enhances the effect of the PNPLA3 I148M variant on the liver. We also show that specific nutrients interact with the PNPLA3 I148M variant in modulating liver disease susceptibility. (C) 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Keyword

PNPLA3 rs738409

Adiponutrin

Nutrigenetics

Obesity

Liver steatosis

DOMAIN-CONTAINING 3

CHRONIC HEPATITIS-C

FATTY LIVER

HEPATOCELLULAR-CARCINOMA

HEREDITARY HEMOCHROMATOSIS

ALCOHOL INTAKE

CHILDHOOD BMI

WEIGHT-LOSS

RISK

STEATOSIS

Food Science & Technology

Publication and Content Type

ref (subject category)

art (subject category)