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- Buhmann, H. (author)
The gut-brain axis in obesity
- Article/chapterEnglish2014
Publisher, publication year, extent ...
- Elsevier BV,2014
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/205863
- https://gup.ub.gu.se/publication/205863URI
- https://doi.org/10.1016/j.bpg.2014.07.003DOI
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- Language:English
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Notes
- Currently the only effective treatment for morbid obesity with a proven mortality benefit is surgical intervention. The underlying mechanisms of these surgical techniques are unclear, but alterations in circulating gut hormone levels have been demonstrated to be at least one contributing factor. Gut hormones seem to communicate information from the gastrointestinal tract to the regulatory appetite centres within the central nervous system (CNS) via the so-called 'Gut-Brain-Axis'. Such information may be transferred to the CNS either via vagal or non-vagal afferent nerve signalling or directly via blood circulation. Complex neural networks, distributed throughout the forebrain and brainstem, are in control of feeding and energy homoeostasis. This article aims to review how appetite is potentially regulated by these gastrointestinal hormones. Identification of the underlying mechanisms of appetite and weight control may pave the way to develop better surgical techniques and new therapies in the future.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
- Obesity
- Appetite
- Gastrointestinal hormones
- Glucagon-like-peptide 1 (GLP-1)
- Hypothalamus
- GLUCAGON-LIKE PEPTIDE-1
- GASTRIC-INHIBITORY POLYPEPTIDE
- REDUCES
- FOOD-INTAKE
- BODY-WEIGHT GAIN
- DEPENDENT INSULINOTROPIC POLYPEPTIDE
- NERVOUS-SYSTEM CONTROL
- PLASMA GHRELIN LEVELS
- ENERGY HOMEOSTASIS
- PANCREATIC-POLYPEPTIDE
- NEUROPEPTIDE-Y
Added entries (persons, corporate bodies, meetings, titles ...)
- le Roux, Carel WGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning,Institute of Clinical Sciences, Department of Gastrosurgical Research and Education(Swepub:gu)xleroc (author)
- Bueter, M. (author)
- Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning (creator_code:org_t)
Related titles
- In:Best Practice & Research in Clinical Gastroenterology: Elsevier BV28:4, s. 559-5711521-6918
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