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A filter-flow persp...
A filter-flow perspective of haematogenous metastasis offers a non-genetic paradigm for personalised cancer therapy
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- Scott, Jacob G (författare)
- H. Lee Moffitt Cancer Center and Research Institute,University Of Oxford
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- Fletcher, Alexander G (författare)
- University Of Oxford
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- Maini, Philip K (författare)
- University Of Oxford
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- Anderson, Alexander R.A. (författare)
- H. Lee Moffitt Cancer Center and Research Institute
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- Gerlee, Philip, 1980 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematik,Department of Mathematical Sciences, Mathematics,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg
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H Lee Moffitt Cancer Center and Research Institute University Of Oxford (creator_code:org_t)
- Elsevier BV, 2014
- 2014
- Engelska.
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Ingår i: European Journal of Cancer. - : Elsevier BV. - 0959-8049. ; 50:17, s. 3068-3075
- Relaterad länk:
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https://europepmc.or...
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Research into mechanisms of haematogenous metastasis has largely become genetic in focus, attempting to understand the molecular basis of ‘seed–soil’ relationships. Preceding this biological mechanism is the physical process of dissemination of circulating tumour cells (CTCs) in the circulation. Patterns of metastatic spread have been previously quantified using the metastatic efficiency index, a measure quantifying metastatic incidence for a given primary-target organ pair and the relative blood flow between them. We extend this concept to take into account the reduction in CTCs which occurs in organ capillary beds connected by a realistic vascular network topology. Application to a dataset of metastatic incidence reveals that metastatic patterns depend strongly on assumptions about the existence and location of micrometastatic disease which governs CTC dynamics on the network, something which has heretofore not been considered – an oversight which precludes our ability to predict metastatic patterns in individual patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- NATURVETENSKAP -- Matematik -- Annan matematik (hsv//swe)
- NATURAL SCIENCES -- Mathematics -- Other Mathematics (hsv//eng)
Nyckelord
- Mathematical model
- Metastasis
- Oligometastasis
- Circulating tumour cells
- Mathematical model
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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