Microwave-Based Stroke Diagnosis Making Global Prehospital Thrombolytic Treatment Possible

Persson, Mikael,1959Chalmers tekniska högskola,Chalmers University of Technology (author)

Here, we present two different brain diagnostic devices based on microwave technology and the associated two first proof-of-principle measurements that show that the systems can differentiate hemorrhagic from ischemic stroke in acute stroke patients, as well as differentiate hemorrhagic patients from healthy volunteers. The system was based on microwave scattering measurements with an antenna system worn on the head. Measurement data were analyzed with a machine-learning algorithm that is based on training using data from patients with a known condition. Computer tomography images were used as reference. The detection methodology was evaluated with the leave-one-out validation method combined with a Monte Carlo-based bootstrap step. The clinical motivation for this project is that ischemic stroke patients may receive acute thrombolytic treatment at hospitals, dramatically reducing or abolishing symptoms. A microwave system is suitable for prehospital use, and therefore has the potential to allow significantly earlier diagnosis and treatment than today.

Fhager, Andreas,1976Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)elfad (author)
Dobsicek Trefna, Hana,1979Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)hanatre (author)
Yu, Yinan,1985Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)yinan (author)
McKelvey, Tomas,1966Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)mckelvey (author)
Pegenius, GöranGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation,University of Gothenburg(Swepub:gu)xpeggo (author)
Karlsson, J. E.Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital (author)
Elam, Mikael,1956Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation,University of Gothenburg(Swepub:gu)xelami (author)
Chalmers tekniska högskolaInstitutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering (creator_code:org_t)

In:IEEE Transactions on Biomedical Engineering: Institute of Electrical and Electronics Engineers (IEEE)61:11, s. 2806-28170018-92941558-2531

By the author/editor: Persson, Mikael, ...; Fhager, Andreas, ...; Dobsicek Trefna, ...; Yu, Yinan, 1985; McKelvey, Tomas, ...; Pegenius, Göran; show more...; Karlsson, J. E.; Elam, Mikael, 19 ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Physiology

ENGINEERING AND TECHNOLOGY: ENGINEERING AND ...; and Industrial Biote ...; and Medical Biotechn ...

By the university: University of Gothenburg; Chalmers University of Technology

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