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Osteoblast-derived ...
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Movérare-Skrtic, SofiaGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden
(author)
Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures.
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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2014-10-12
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Springer Science and Business Media LLC,2014
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/208033
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https://gup.ub.gu.se/publication/208033URI
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https://doi.org/10.1038/nm.3654DOI
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https://research.chalmers.se/publication/208033URI
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https://lup.lub.lu.se/record/4737118URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-97227URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-111388URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:130112535URI
Supplementary language notes
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The WNT16 locus is a major determinant of cortical bone thickness and nonvertebral fracture risk in humans. The disability, mortality and costs caused by osteoporosis-induced nonvertebral fractures are enormous. We demonstrate here that Wnt16-deficient mice develop spontaneous fractures as a result of low cortical thickness and high cortical porosity. In contrast, trabecular bone volume is not altered in these mice. Mechanistic studies revealed that WNT16 is osteoblast derived and inhibits human and mouse osteoclastogenesis both directly by acting on osteoclast progenitors and indirectly by increasing expression of osteoprotegerin (Opg) in osteoblasts. The signaling pathway activated by WNT16 in osteoclast progenitors is noncanonical, whereas the pathway activated in osteoblasts is both canonical and noncanonical. Conditional Wnt16 inactivation revealed that osteoblast-lineage cells are the principal source of WNT16, and its targeted deletion in osteoblasts increases fracture susceptibility. Thus, osteoblast-derived WNT16 is a previously unreported key regulator of osteoclastogenesis and fracture susceptibility. These findings open new avenues for the specific prevention or treatment of nonvertebral fractures, a substantial unmet medical need.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Henning, Petra,1974Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden(Swepub:gu)xhenpe
(author)
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Liu, XianwenWest China Hospital,Southern Medical University,Harvard School of Dental Medicine, Boston, Massachusetts, USA; Sichuan University, China
(author)
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Nagano, KenichiHarvard School of Dental Medicine, Boston, Massachusetts, USA
(author)
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Saito, HiroakiUniversitatsklinikum Hamburg-Eppendorf und Medizinische Fakultat,Harvard School of Dental Medicine, Boston, Massachusetts, USA
(author)
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Börjesson, Anna EGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden(Swepub:gu)xbannf
(author)
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Sjögren, Klara,1970Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden(Swepub:gu)xsjokl
(author)
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Windahl, Sara H,1971Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden(Swepub:gu)xwinds
(author)
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Farman, Helen H.,1983Karolinska Institutet,Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden(Swepub:gu)xfarhe
(author)
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Kindlund, Bert,1969Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin,Institute of Medicine,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden(Swepub:gu)xkinbe
(author)
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Engdahl, Cecilia,1983Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Rheumatology and Inflammation Research,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden(Swepub:gu)xhakce
(author)
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Koskela, AnttiOulun Yliopisto,University of Oulu,University of Oulu, Finland
(author)
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Zhang, Fu-PingTurun Yliopisto,University of Turku,University of Turku, Finland
(author)
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Eriksson, Emma EKarolinska Institutet,Karolinska Institutet, Pediatric Endocrinology Unit, Stockholm, Sweden
(author)
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Zaman, FarasatKarolinska Institutet,Karolinska Institutet, Pediatric Endocrinology Unit, Stockholm, Sweden
(author)
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Hammarstedt, Ann,1975Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden(Swepub:gu)xhaman
(author)
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Isaksson, HannaLund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Lund University, Sweden(Swepub:lu)soli-hai
(author)
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Bally, Marta,1981Chalmers tekniska högskola,Chalmers University of Technology,Chalmers University of Technology, Gothenburg, Sweden.(Swepub:cth)bally
(author)
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Kassem, AliUmeå universitet,Institutionen för odontologi,Umeå University, Sweden(Swepub:umu)alka0011
(author)
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Lindholm, Catharina,1967Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden(Swepub:gu)xlicat
(author)
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Sandberg, OlofLinköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet(Swepub:liu)olosa45
(author)
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Aspenberg, PerÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Ortopedkliniken i Linköping(Swepub:liu)peras36
(author)
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Sävendahl, LarsKarolinska Institutet
(author)
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Feng, Jian QTexas A&M Health Science Center, Dallas, Texas, USA
(author)
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Tuckermann, JanUniversität Ulm,University of Ulm,University of Ulm, Germany
(author)
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Tuukkanen, JuhaOulun Yliopisto,University of Oulu,University of Oulu, Finland
(author)
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Poutanen, MattiGothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden(Swepub:gu)xpouma
(author)
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Baron, RolandMassachusetts General Hospital,Harvard School of Dental Medicine, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA
(author)
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Lerner, Ulf HUmeå universitet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg,Institutionen för odontologi,Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden(Swepub:umu)ulle0001
(author)
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Gori, FrancescaMassachusetts General Hospital,Harvard School of Dental Medicine, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA
(author)
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Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden(Swepub:gu)xohlcl
(author)
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Göteborgs universitetInstitutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition
(creator_code:org_t)
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In:Nature Medicine: Springer Science and Business Media LLC20:11, s. 1279-881078-89561546-170X
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Movérare-Skrtic, ...
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Henning, Petra, ...
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Liu, Xianwen
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Nagano, Kenichi
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Saito, Hiroaki
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Börjesson, Anna ...
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Sjögren, Klara, ...
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Windahl, Sara H, ...
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Farman, Helen H. ...
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Kindlund, Bert, ...
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Engdahl, Cecilia ...
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Koskela, Antti
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Zhang, Fu-Ping
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Eriksson, Emma E
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Zaman, Farasat
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Hammarstedt, Ann ...
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Isaksson, Hanna
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Bally, Marta, 19 ...
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Kassem, Ali
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Lindholm, Cathar ...
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Sandberg, Olof
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Aspenberg, Per
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Sävendahl, Lars
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Feng, Jian Q
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Tuckermann, Jan
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Tuukkanen, Juha
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Poutanen, Matti
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Baron, Roland
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Lerner, Ulf H
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Gori, Francesca
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Ohlsson, Claes, ...
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