Waterborne beclomethasone dipropionate affects the physiology of fish while its metabolite beclomethasone is not taken up

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Carney Almroth, Bethanie,1974Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,University of Gothenburg (author)

Waterborne beclomethasone dipropionate affects the physiology of fish while its metabolite beclomethasone is not taken up

Article/chapterEnglish2015

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Elsevier BV,2015

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LIBRIS-ID:oai:gup.ub.gu.se/208518
https://gup.ub.gu.se/publication/208518URI
https://doi.org/10.1016/j.scitotenv.2014.12.016DOI
https://research.chalmers.se/publication/208518URI
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-102441URI

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Language:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Asthma is commonly treated with inhalable glucocorticosteroids, including beclomethasone dipropionate (BDP). This is a synthetic prodrug which is metabolized to the more active monopropionate (BMP) and free beclomethasone in humans. To evaluate potential effects of residual drugs on fish, we conducted a 14 day flow-through exposure experiment with BDP and beclomethasone using rainbow trout, and analyzed effects on plasma glucose, hepatic glutathione and catalase activity together with water and body concentrations of the BDP, BMP and beclomethasone. We also analyzed hepatic gene expression in BDP-exposed fish by microarray and quantitative PCR. Beclomethasone (up to 0.65 μg/L) was not taken up in the fish while BDP (0.65 and 0.07 μg/L) resulted in accumulation of both beclomethasone, BMP and BDP in plasma, reaching levels up to those found in humans during therapy. Accordingly, exposure to 0.65 μg/L of BDP significantly increased blood glucose as well as oxidized glutathione levels and catalase activity in the liver. Exposure to beclomethasone or the low concentration of BDP had no effect on these endpoints. Both exposure concentrations of BDP resulted in significantly higher transcript abundance of phosphoenolpyruvate carboxykinase involved in gluconeogenesis, and of genes involved in immune responses. As only the rapidly metabolized prodrug was potent in fish, the environmental risks associated with the use of BDP are probably small. However, the observed physiological effects in fish of BDP at plasma concentrations known to affect human physiology provides valuable input to the development of read-across approaches in the identification of pharmaceuticals of environmental concern.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmakologi och toxikologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmacology and Toxicology hsv//eng
NATURVETENSKAP Biologi Zoologi hsv//swe
NATURAL SCIENCES Biological Sciences Zoology hsv//eng
NATURVETENSKAP Biologi hsv//swe
NATURAL SCIENCES Biological Sciences hsv//eng
NATURVETENSKAP Kemi Organisk kemi hsv//swe
NATURAL SCIENCES Chemical Sciences Organic Chemistry hsv//eng
Beclomethasone dipropionate
Rainbow trout
Environmental risk assessment
Gene expression
Asthma medicine
Glucocorticoid
Rainbow trout

Added entries (persons, corporate bodies, meetings, titles ...)

Gunnarsson, Lina-Maria,1977Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg(Swepub:gu)xgunli (author)
Cuklev Stern, Filip,1981Gothenburg University,Göteborgs universitet,Core Facilities, Genomics,Core Facilities, Genomics,University of Gothenburg(Swepub:gu)xcufil (author)
Fick, JerkerUmeå universitet,Kemiska institutionen(Swepub:umu)jefi0001 (author)
Kristiansson, Erik,1978Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg(Swepub:cth)erikkr (author)
Larsson, D. G. Joakim,1969Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg(Swepub:gu)xlarjo (author)
Göteborgs universitetInstitutionen för neurovetenskap och fysiologi (creator_code:org_t)

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In:Science of the Total Environment: Elsevier BV511, s. 37-460048-96971879-1026

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