Relation of Serum Uric Acid Levels and Outcomes Among Patients Hospitalized for Worsening Heart Failure With Reduced Ejection Fraction (from the Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study With Tolvaptan Trial)

We investigated the clinical profiles associated with serum uric acid (sUA) levels in a large cohort of patients hospitalized for worsening chronic heart failure with ejection fraction (EF) /=30 ml/min/1.73 m(2), sUA was strongly associated with increased all-cause mortality (hazard ratio 1.44, 95% confidence interval 1.22 to 1.69, p <0.001) and the composite end point (hazard ratio 1.44, 95% confidence interval 1.26 to 1.64, p <0.001). However, in patients with estimated glomerular filtration rate <30 ml/min/1.73 m(2), sUA was not related with either end point (both p >0.4). Adjusted interaction analyses for gender, race, and admission allopurinol use were not significant. In conclusion, sUA is commonly elevated in patients hospitalized for worsening chronic heart failure and reduced EF, especially in men and blacks. The prognostic use of sUA differs by baseline renal function, suggesting different biologic and pathophysiologic significance of sUA among those with and without significant renal dysfunction.

Greene, S. J. (author)
Ambrosy, A. P. (author)
Mentz, R. J. (author)
Subacius, H. P. (author)
Chioncel, O. (author)
Maggioni, A. P. (author)
Swedberg, Karl,1944Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xsweka (author)
Zannad, F. (author)
Konstam, M. A. (author)
Senni, M. (author)
Givertz, M. M. (author)
Butler, J. (author)
Gheorghiade, M. (author)
Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin (creator_code:org_t)

By the author/editor: Vaduganathan, M.; Greene, S. J.; Ambrosy, A. P.; Mentz, R. J.; Subacius, H. P.; Chioncel, O.; show more...; Maggioni, A. P.; Swedberg, Karl, ...; Zannad, F.; Konstam, M. A.; Senni, M.; Givertz, M. M.; Butler, J.; Gheorghiade, M.; show less...

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