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  • Hollerhage, M. (author)

Piericidin A Aggravates Tau Pathology in P301S Transgenic Mice

  • Article/chapterEnglish2014

Publisher, publication year, extent ...

  • 2014-12-01
  • Public Library of Science (PLoS),2014

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/212018
  • https://gup.ub.gu.se/publication/212018URI
  • https://doi.org/10.1371/journal.pone.0113557DOI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Objective: The P301S mutation in exon 10 of the tau gene causes a hereditary tauopathy. While mitochondrial complex I inhibition has been linked to sporadic tauopathies. Piericidin A is a prototypical member of the group of the piericidins, a class of biologically active natural complex I inhibitors, isolated from streptomyces spp. with global distribution in marine and agricultural habitats. The aim of this study was to determine whether there is a pathogenic interaction of the environmental toxin piericidin A and the P301S mutation. Methods: Transgenic mice expressing human tau with the P301S-mutation (P301S(+/+)) and wild-type mice at 12 weeks of age were treated subcutaneously with vehicle (N=10 P301S(+/+), N = 7 wild-type) or piericidin A (N = 9 P301S(+/+), N = 9 wild-type mice) at a dose of 0.5 mg/kg/d for a period of 28 days via osmotic minipumps. Tau pathology was measured by stereological counts of cells immunoreative with antibodies against phosphorylated tau (AD2, AT8, AT180, and AT100) and corresponding Western blot analysis. Results: Piericidin A significantly increased the number of phospho-tau immunoreactive cells in the cerebral cortex in P301S(+/+) mice, but only to a variable and mild extent in wild-type mice. Furthermore, piericidin A led to increased levels of pathologically phosphorylated tau only in P301S(+/+) mice. While we observed no apparent cell loss in the frontal cortex, the synaptic density was reduced by piericidin A treatment in P301S(+/+) mice. Discussion: This study shows that exposure to piericidin A aggravates the course of genetically determined tau pathology, providing experimental support for the concept of gene-environment interaction in the etiology of tauopathies.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Deck, R. (author)
  • de Andrade, A. (author)
  • Respondek, G. (author)
  • Xu, H. (author)
  • Rosler, T. W. (author)
  • Salama, M. (author)
  • Carlsson, Thomas,1977Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology(Swepub:gu)xcatho (author)
  • Yamada, E. S. (author)
  • El Hak, S. A. G. (author)
  • Goedert, M. (author)
  • Oertel, W. H. (author)
  • Hoglinger, G. U. (author)
  • Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för farmakologi (creator_code:org_t)

Related titles

  • In:Plos One: Public Library of Science (PLoS)9:121932-6203

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