Genotoxic effects of CdS quantum dots and Ag2S nanoparticles in fish cell lines (RTG-2)

• The increasing use of nanotechnologies will lead to significant releases of engineered nanoparticles into the aquatic environment, where their impact is still poorly characterized. In the present paper, the genotoxic and cytotoxic properties of CdS quantum dots (QDs) and silver sulphide (Ag2S) coated with methyl polyethylene glycol (M-PEG) were investigated in a rainbow trout cell line (RTG-2). The results showed that CdS QDs were highly cytotoxic at high concentrations (10 and 50 mu g/ml), and exhibited a concentration-dependent genotoxicity in the sub-toxic range (0.01-1 mu g/ml) after 24h exposure. Ag2S showed neither genotoxic nor cytotoxic effects. (C) 2014 Elsevier B.V. All rights reserved.

Ämnesord

NATURVETENSKAP  -- Biologi -- Genetik (hsv//swe)

NATURAL SCIENCES  -- Biological Sciences -- Genetics (hsv//eng)

Nyckelord

DNA damage

Fish cell culture

Nanoparticles

Quantum dots

Silver

Cadmium

IN-VITRO

SILVER NANOPARTICLES

COMET ASSAY

RAINBOW-TROUT

DNA-DAMAGE

MYTILUS-GALLOPROVINCIALIS

OXIDATIVE STRESS

IMMUNE-SYSTEM

LIVE CELLS

TOXICITY

Biotechnology & Applied Microbiology

Genetics & Heredity

Toxicology

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